Controlled drug delivery vehicles for cancer treatment and their performance
Open accessAbstract
Although conventional chemotherapy has been successful to some extent, the main drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting. The main aim in the development of drug delivery vehicles is to successfully address these delivery-related problems and carry drugs to the desired sites of therapeutic action while reducing adverse side effects. In this review, we will discuss the different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs and will describe recent scientific advances in the area of chemotherapy, emphasizing challenges in cancer treatments.
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After modification or stimulation by corresponding factors, smart nanoparticles efficiently aggregate at the target location and release their payloads.
“After modification or stimulation by corresponding factors, these smart nanoparticles efficiently aggregate at the target location and release their payloads, establishing a smart treatment mode.8–12”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [12]
The first commercially available drug licensed by the FDA that has demonstrated notable efficacy in the treatment of metastatic breast cancer is Abraxane, which has a diameter of about 130 nm.
“The first commercially available drug licensed by the Food and Drug Administration (FDA) that has demonstrated notable efficacy in the treatment of metastatic breast cancer is called Abraxane, which has a diameter of about 130 nm.12”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [12]
Efficacy of drug delivery vehicles depends on their size, shape, hydrophobicity, surface parameters, and other chemical and biophysical features.
“However, the efficacy of these drug delivery vehicles depends on their size, shape, hydrophobicity, surface parameters, and several other chemical and biophysical features.6,7”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [7]
Nanomedicines are able to reach distant and specific sites of body because of nanosized structure.
“Because of the nanosized structure, nanomedicines are able to reach distant and specific sites of the body.7”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [7]
Versatile materials including polymers, lipids, inorganic molecules, hydrogels, and macromolecular scaffolds have led to the development of systems that deliver chemotherapeutics directly to tumor sites with improved therapeutic efficacy.
“So far, versatile materials are used, including polymers,221 lipids,222 inorganic molecules, hydrogels,223 and macromolecular scaffolds,224 which have led to the development of systems that deliver chemotherapeutics directly to the tumor sites with improved therapeutic efficacy.7”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [7]
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References 206 · Cited by 2,167
- Authors
- Senapati, S., Mahanta, A. K., Kumar, S., & Maiti, P.
- Affiliations
- Indian Institute of Technology BHU (IN)
- Corresponding author
- Maiti, Pralay
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2018-03-16
- Volume
- 3
- Issue
- 1
- Pages
- 7-7
- ISSN
- 2059-3635 (ISSN-L)
- PMC
- PMC5854578
- OpenAlex
- W2807410315
- Cited by
- 2,167
- References
- 206
- Citations by year
- 2026: 110 · 2025: 269 · 2024: 317 · 2023: 348 · 2022: 393 · 2021: 294 · 2020: 248 · 2019: 145 · 2018: 42
- FWCI
- 58.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Science and Engineering Research Board
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- controlled drug delivery, drug carriers, cancer chemotherapy, chemotherapy side effects, drug resistance, targeted drug delivery, bioavailability, nanocarriers
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