The DOI matches its Crossref record.
Evaluation of Uncertainties Associated with the Determination of Community Drug Use through the Measurement of Sewage Drug Biomarkers
Abstract
The aim of this study was to integrally address the uncertainty associated with all the steps used to estimate community drug consumption through the chemical analysis of sewage biomarkers of illicit drugs. Uncertainty has been evaluated for sampling, chemical analysis, stability of drug biomarkers in sewage, back-calculation of drug use (specific case of cocaine), and estimation of population size in a catchment using data collected from a recent Europe-wide investigation and from the available literature. The quality of sampling protocols and analytical measurements has been evaluated by analyzing standardized questionnaires collected from 19 sewage treatments plants (STPs) and the results of an interlaboratory study (ILS), respectively. Extensive reviews of the available literature have been used to evaluate stability of drug biomarkers in sewage and the uncertainty related to back-calculation of cocaine use. Different methods for estimating population size in a catchment have been compared and the variability among the collected data was very high (7-55%). A reasonable strategy to reduce uncertainty was therefore to choose the most reliable estimation case by case. In the other cases, the highest uncertainties are related to the analysis of sewage drug biomarkers (uncertainty as relative standard deviation; RSD: 6-26% from ILS) and to the back-calculation of cocaine use (uncertainty; RSD: 26%). Uncertainty can be kept below 10% in the remaining steps, if specific requirements outlined in this work are considered. For each step, a best practice protocol has been suggested and discussed to reduce and keep to a minimum the uncertainty of the entire procedure and to improve the reliability of the estimates of drug use.
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Citations
Cited by
Sims, N., & Kasprzyk-Hordern, B. (2020) · Environment International · doi:10.1016/j.envint.2020.105689 · Cited by 665
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Choi, P. M., Tscharke, B. J., Donner, E., O'Brien, J. W., Grant, S. C., Kaserzon, S. L., Mackie, R., O'Malley, E., Crosbie, N. D., Thomas, K. V., et al. (2018) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2018.06.004 · Cited by 486
Self-citationMind the gap: persistent and mobile organic compounds—water contaminants that slip through
Reemtsma, T., Berger, U., Arp, H. P. H., Gallard, H., Knepper, T. P., Neumann, M., Quintana, J. B., & Voogt, P. D. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b03338 · Cited by 424
Self-citationGraham, K. E., Loeb, S. K., Wolfe, M. K., Catoe, D., Sinnott-Armstrong, N., Kim, S., Yamahara, K. M., Sassoubre, L. M., Mendoza Grijalva, L. M., Roldan-Hernandez, L., et al. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.0c06191 · Cited by 363
Critical review on the stability of illicit drugs in sewers and wastewater samples
McCall, A.-K., Bade, R., Kinyua, J., Lai, F. Y., Thai, P. K., Covaci, A., Bijlsma, L., van Nuijs, A. L. N., & Ort, C. (2016) · Water Research · doi:10.1016/j.watres.2015.10.040 · Cited by 311
Self-citationThree years of wastewater surveillance for new psychoactive substances from 16 countries
Bade, R., Rousis, N., Adhikari, S., Baduel, C., Bijlsma, L., Bizani, E., Boogaerts, T., Burgard, D. A., Castiglioni, S., Chappell, A., et al. (2023) · Water Research X · doi:10.1016/j.wroa.2023.100179 · Cited by 53
Self-citationSalgueiro-Gonzalez, N., Béen, F., Bijlsma, L., Boogaerts, T., Covaci, A., Baz-Lomba, J. A., Kasprzyk-Hordern, B., Matias, J., Ort, C., Bodík, I., et al. (2024) · Water Research · doi:10.1016/j.watres.2024.121390 · Cited by 51
Self-citationUse of legal and illegal substances in Malé (Republic of Maldives) assessed by wastewater analysis
Fallati, L., Castiglioni, S., Galli, P., Riva, F., Gracia-Lor, E., González-Mariño, I., Rousis, N. I., Shifah, M., Messa, M. C., Strepparava, M. G., et al. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.134207 · Cited by 43
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Metadata
- Authors
- Castiglioni, S., Bijlsma, L., Covaci, A., Emke, E., Hernández, F., Reid, M., Ort, C., Thomas, K. V., van Nuijs, A. L. N., de Voogt, P., & Zuccato, E.
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-02-05
- Volume
- 47
- Issue
- 3
- Pages
- 1452-1460
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W2060880041
- Cited by
- 402
- References
- 0
- FWCI
- 12.84
- Type
- journal article
- Language
- en
- Open access
- closed
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