The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Evolutionary Conservation of Human Drug Targets in Organisms used for Environmental Risk Assessments
Abstract
Pharmaceuticals are typically found in very low concentrations in the aquatic environment. Accordingly, environmental effects clearly assigned to residual drugs are consistent with high affinity interactions with conserved targets in affected wildlife species rather than with a general toxic effect. Thus, evolutionarily well-conserved targets in a given species are associated with an increased risk. In this study orthologs for 1318 human drug targets were predicted in 16 species of which several are relevant for ecotoxicity testing. The conservation of different functional categories of targets was also analyzed. Zebrafish had orthologs to 86% of the drug targets while only 61% were conserved in Daphnia and 35% in green alga. The predicted presence and absence of orthologs agrees well with published experimental data on the potential for specific drug target interaction in various species. Based on the conservation of targets we propose that aquatic environmental risk assessments for human drugs should always include comprehensive studies on aquatic vertebrates. Furthermore, individual targets, especially enzymes, are well conserved suggesting that tests on evolutionarily distant organisms would be highly relevant for certain drugs. We propose that the results can guide environmental risk assessments by improving the possibilities to identify species sensitive to certain types of pharmaceuticals or to other contaminants that act through well defined mechanisms of action. Moreover, we suggest that the results can be used to interpret the relevance of existing ecotoxicity data.
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Ecological effects of pharmaceuticals in aquatic systems—impacts through behavioural alterations
Brodin, T., Piovano, S., Fick, J., Klaminder, J., Heynen, M., & Jonsson, M. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0580 · Cited by 499
Gaballah, S., Swank, A., Sobus, J. R., Howey, X. M., Schmid, J., Catron, T., McCord, J., Hines, E., Strynar, M., & Tal, T. (2020) · Environmental Health Perspectives · doi:10.1289/ehp5843 · Cited by 437
Metformin and Other Pharmaceuticals Widespread in Wadeable Streams of the Southeastern United States
Bradley, P. M., Journey, C. A., Button, D. T., Carlisle, D. M., Clark, J. M., Mahler, B. J., Nakagaki, N., Qi, S. L., Waite, I. R., & VanMetre, P. C. (2016) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.6b00170 · Cited by 115
Screening of Benzodiazepines in Thirty European Rivers
Fick, J., Brodin, T., Heynen, M., Klaminder, J., Jonsson, M., Grabicova, K., Randak, T., Grabic, R., Kodes, V., Slobodnik, J., et al. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.02.126 · Cited by 76
Metadata
- Authors
- Gunnarsson, L., Jauhiainen, A., Kristiansson, E., Nerman, O., & Larsson, D. G. J.
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-06-25
- Volume
- 42
- Issue
- 15
- Pages
- 5807-5813
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W2026765020
- Cited by
- 594
- References
- 13
- FWCI
- 21.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gunnarsson, L., Jauhiainen, A., Kristiansson, E., Nerman, O., & Larsson, D. G. J. (2008). Evolutionary Conservation of Human Drug Targets in Organisms used for Environmental Risk Assessments. Environmental Science & Technology. https://doi.org/10.1021/es8005173
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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