The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Ecological effects of pharmaceuticals in aquatic systems—impacts through behavioural alterations
Open accessAbstract
The study of animal behaviour is important for both ecology and ecotoxicology, yet research in these two fields is currently developing independently. Here, we synthesize the available knowledge on drug-induced behavioural alterations in fish, discuss potential ecological consequences and report results from an experiment in which we quantify both uptake and behavioural impact of a psychiatric drug on a predatory fish (Perca fluviatilis) and its invertebrate prey (Coenagrion hastulatum). We show that perch became more active while damselfly behaviour was unaffected, illustrating that behavioural effects of pharmaceuticals can differ between species. Furthermore, we demonstrate that prey consumption can be an important exposure route as on average 46% of the pharmaceutical in ingested prey accumulated in the predator. This suggests that investigations of exposure through bioconcentration, where trophic interactions and subsequent bioaccumulation of exposed individuals are ignored, underestimate exposure. Wildlife may therefore be exposed to higher levels of behaviourally altering pharmaceuticals than predictions based on commonly used exposure assays and pharmaceutical concentrations found in environmental monitoring programmes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Developmental effects of endocrine-disrupting chemicals in wildlife and humans.
Colborn, T., vom Saal, F. S., & Soto, A. M. (1993) · Environmental Health Perspectives · doi:10.1289/ehp.93101378 · Cited by 3,445
Brooks, J. L., & Dodson, S. I. (1965) · Science · doi:10.1126/science.150.3692.28 · Cited by 3,280
Krause, J., & Ruxton, G. D. (2002) · doi:10.1093/oso/9780198508175.001.0001 · Cited by 3,189
Quantifying the evidence for biodiversity effects on ecosystem functioning and services
Balvanera, P., Pfisterer, A. B., Buchmann, N., He, J., Nakashizuka, T., Raffaelli, D., & Schmid, B. (2006) · Ecology Letters · doi:10.1111/j.1461-0248.2006.00963.x · Cited by 2,650
Verlicchi, P., Al Aukidy, M., & Zambello, E. (2012) · Science of The Total Environment · doi:10.1016/j.scitotenv.2012.04.028 · Cited by 2,183
Collapse of a fish population after exposure to a synthetic estrogen
Kidd, K. A., Blanchfield, P. J., Mills, K. H., Palace, V. P., Evans, R. E., Lazorchak, J. M., & Flick, R. W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609568104 · Cited by 2,094
Behavioral Syndromes: An Integrative Overview
Sih, A., Bell, A. M., Johnson, J. C., & Ziemba, R. E. (2004) · The Quarterly Review of Biology · doi:10.1086/422893 · Cited by 2,048
Predation: Direct and Indirect Impacts on Aquatic Communities
Crowder, L. B., Kerfoot, W. C., & Sih, A. (1988) · Copeia · doi:10.2307/1445906 · Cited by 1,899
A REVIEW OF TRAIT-MEDIATED INDIRECT INTERACTIONS IN ECOLOGICAL COMMUNITIES
Werner, E. E., & Peacor, S. D. (2003) · Ecology · doi:10.1890/0012-9658(2003)084[1083:arotii]2.0.co;2 · Cited by 1,689
Fitness consequences of personality: a meta-analysis
Smith, B. R., & Blumstein, D. T. (2008) · Behavioral Ecology · doi:10.1093/beheco/arm144 · Cited by 1,450
Cited by
Pharmaceuticals and personal care products (PPCPs) in the freshwater aquatic environment
Ebele, A. J., Abou-Elwafa Abdallah, M., & Harrad, S. (2017) · Emerging Contaminants · doi:10.1016/j.emcon.2016.12.004 · Cited by 2,023
Screening of Benzodiazepines in Thirty European Rivers
Fick, J., Brodin, T., Heynen, M., Klaminder, J., Jonsson, M., Grabicova, K., Randak, T., Grabic, R., Kodes, V., Slobodnik, J., et al. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.02.126 · Cited by 76
Self-citationEgan, N., Stinson, S. A., Deng, X., Lawler, S. P., & Connon, R. E. (2023) · Biology · doi:10.3390/biology12030425 · Cited by 24
Hof, M. A. J., de Haan, H., Stepanovic, S., Bakker, S. J. L., Hak, E., Hopfgartner, G., Klont, F., & Investigators, T. (2025) · Metabolites · doi:10.3390/metabo15070473 · Cited by 1
“The consequences of such contamination can affect the health and behavior of organisms living in this ecosystem and potentially pose risks to human health [4,5].”
Metadata
- Authors
- Brodin, T., Piovano, S., Fick, J., Klaminder, J., Heynen, M., & Jonsson, M.
- Venue
- Philosophical Transactions of the Royal Society B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2014-11-19
- Volume
- 369
- Issue
- 1656
- Pages
- 20130580
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- OpenAlex
- W2154472922
- Cited by
- 499
- References
- 88
- FWCI
- 17.57
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Ecological effects of pharmaceuticals in aquatic systems—impacts through behavioural alterations. https://app.cochat.ai/papers/10.1098/rstb.2013.0580
- The paper
- Brodin, T., Piovano, S., Fick, J., Klaminder, J., Heynen, M., & Jonsson, M. (2014). Ecological effects of pharmaceuticals in aquatic systems—impacts through behavioural alterations. Philosophical Transactions of the Royal Society B: Biological Sciences. https://doi.org/10.1098/rstb.2013.0580
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
