The DOI matches its Crossref record.
Microcalorimetric detection of lower critical solution temperatures in aqueous polymer solutions
Abstract
A sensitive solution microcalorimeter was used to study lower critical solution temperatures (LCSTs) of aqueous polymer solutions. Endotherms with enthalpies on the order of the strength of hydrogen bonds were observed at temperatures concurring with LCSTs detected by classical cloud-point measurements for solutions of poly(N-isopropylacrylamide) (PNIPAAM), poly(vinyl methyl ether) (PVME), poly(propylene glycol) (PPG), and hydroxypropylcelluloe (HPC). The LCST of PNIPAAM was found to be dependent on the chain length, generally increasing with decreasing M-bar_n in the range M-bar_n = 1.6 X 10^5 to 5.4 X 10^3. Treatment of the calorimetric endotherm according to a two-state transiton model afforded cooperative unit sizes of the order of the chain length for PNIPAAM, PVME, and PPG. The apparent cooperative unit for the demixing transition of HPC was found to be larger than a single chain, consistent with previous observations of aggregation of HPC below the LCST. Depression of the LCST by added salts was observed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Thermoresponsive hydrogels in biomedical applications
Klouda, L., & Mikos, A. G. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.02.025 · Cited by 1,349
Vihola, H., Laukkanen, A., Valtola, L., Tenhu, H., & Hirvonen, J. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.09.008 · Cited by 689
Xia, Y., Yin, X., Burke, N. A. D., & Stöver, H. D. H. (2005) · Macromolecules · doi:10.1021/ma050261z · Cited by 503
Drug targeting using thermally responsive polymers and local hyperthermia
Meyer, D. E., Shin, B. C., Kong, G. A., Dewhirst, M. W., & Chilkoti, A. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00319-4 · Cited by 416
Thermo-sensitive hydrogels for delivering biotherapeutic molecules: A review
Huang, H., Qi, X., Chen, Y., & Wu, Z. (2019) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2019.08.001 · Cited by 281
Metadata
- Authors
- Schild, H. G., & Tirrell, D. A.
- Venue
- The Journal of Physical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1990-05
- Volume
- 94
- Issue
- 10
- Pages
- 4352-4356
- ISSN
- 0022-3654 (ISSN-L)
- 1541-5740
- OpenAlex
- W1976529631
- Cited by
- 954
- References
- 0
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Microcalorimetric detection of lower critical solution temperatures in aqueous polymer solutions. https://app.cochat.ai/papers/10.1021/j100373a088
- The paper
- Schild, H. G., & Tirrell, D. A. (1990). Microcalorimetric detection of lower critical solution temperatures in aqueous polymer solutions. The Journal of Physical Chemistry. https://doi.org/10.1021/j100373a088
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
