General approach to the synthesis of short .alpha.-helical peptides

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Items 201–300 of 313

1. Stapling of two PEGylated side chains increases the conformational stability of the WW domain via an entropic effect
   Qiang Xiao, Natalie A. Bécar, Nathaniel P. Brown, M.S. Smith, Kimberlee L. Stern, Steven R. E. Draper, Katherine P. Thompson, Joshua L. Price · 2018 · Organic & Biomolecular Chemistry
2. Conformational characterization by circular‐dichroism spectroscopy of various fragments and analogs of calcitonin‐gene‐related peptide
   Murielle Mimeault, Serge St‐Pierre, Alain Fournier · 1993 · European Journal of Biochemistry
3. Stapled peptides: targeting protein-protein interactions in drug development
   Qian Zhang, Ziyang Wang, Xiaohan Mei, Quan Chen, Chunqiu Zhang · 2024 · Exploration of Drug Science
4. Multi-Facial, Non-Peptidic α-Helix Mimetics
   Maryanna E. Lanning, Steven Fletcher · 2015 · Biology
5. Synthetic approaches of naturally and rationally designed peptides and peptidomimetics
   Ariadna Lobo‐Ruiz, Judit Tulla‐Puche · 2017 · Elsevier eBooks
6. Tunable helicity, stability and DNA-binding properties of short peptides with hybrid metal coordination motifs
   Sarah J. Smith, Robert J. Radford, Rohit H. Subramanian, Brandon R. Barnett, Joshua S. Figueroa, F. Akif Tezcan · 2016 · Chemical Science
7. Design, construction and properties of peptide N-terminal cap templates devised to initiate α-helices. Part 1. Caps derived from N-(4-chlorobutyryl)-(2S )-Pro-(2S )-Pro-(2S )-Ala-OMe and N-[(2S )-2-chloropropionyl]-(2S )-Pro-(2S )-Pro-(2S,4S )-4-hydroxyPro-OMe
   Arwel Lewis, Martin D. Ryan, David Gani · 1998 · Journal of the Chemical Society Perkin Transactions 1
8. Backbone cyclic helix mimetic of chemokine (C–C motif) receptor 2: A rational approach for inhibiting dimerization of G protein-coupled receptors
   Mattan Hurevich, Maya Ratner-Hurevich, Yftah Tal‐Gan · 2013 · Bioorganic & Medicinal Chemistry
9. Inhibition of caspase‐9 by stabilized peptides targeting the dimerization interface
   Kristen L. Huber, Sumana Ghosh, Jeanne A. Hardy · 2012 · Biopolymers
10. Influence of α-methylation in constructing stapled peptides with olefin metathesis
    Qingzhou Zhang, Xiaodong Shi, Yan‐Hong Jiang, Zigang Li · 2014 · Tetrahedron
11. Hydrogen bond surrogate stabilized water soluble 310-helix from a disordered pentapeptide containing coded α-amino acids
    Sunit Pal, Erode N. Prabhakaran · 2018 · Tetrahedron Letters
12. Effect of pulsed electric field on diabetes-induced glycated enzyme, oxidative stress, and inflammatory markers in vitro and in vivo
    Alireza Rezaeinezhad, P Eslami, Gh Afrasiabpour, Hossein Mirmiranpour, Hamid Ghomi · 2021 · Journal of Physics D Applied Physics
13. N terminal N -methylation modulates chiral centre induced helical (CIH) peptides’ biophysical properties
    Wenjun Li, Kuan Hu, Qingzhou Zhang, Dongyuan Wang, Yue Ma, Zhanfeng Hou, Feng Yin, Zigang Li · 2018 · Chemical Communications
14. Facile Chemoselective Modification of Thio-Ethers Generates Chiral Center-Induced Helical Peptides
    Zhanfeng Hou, Chengjie Sun, Hao Ran Geng, Kuan Hu, Mingsheng Xie, Yue Ma, Fan Jiang, Feng Yin, Zigang Li · 2018 · Bioconjugate Chemistry
15. Conformational characterization of a helix‐nucleated bicyclic GCN4 decapeptide by proton NMR
    M. Zhang, Bing Yi Wu, Jean Baum · 2000 · Journal of Peptide Research
16. Synthesis of an Orthogonally-Protected Bifunctional Amino Acid for Conformationally Constrained Peptides
    Martin J. I. Andrews, Alethea B. Tabor · 1997 · Tetrahedron Letters
17. Design and synthesis of novel peptides bearing a host and a guest side chains
    Normand Voyer, Brigitte Guérin · 1994 · Tetrahedron
18. Foldamers Based on Remote Intrastrand Interactions
    Philippe Le Grel, Gilles Guichard · 2007 · Wiley eBooks
19. Controlling oncogenic KRAS signaling pathways with a Palladium-responsive peptide
    S. Learte‐Aymamí, P. Martin-Malpartida, Lorena Roldán-Martín, G. Sciortino, J. Couceiro, Jean-Didier Maréchal, M. Macias, J. Mascareñas, M. Vázquez · 2022 · Communications Chemistry
20. Hydrogen bond surrogate helices as minimal mimics of protein α-helices
    Ganesh S. Jedhe, Paramjit S. Arora · 2021 · Methods in enzymology on CD-ROM/Methods in enzymology
21. Intense Blue Fluorescence in a Leucine Zipper Assembly
    Hiroshi Tsutsumi, Seiichiro Abe, Tomoaki Mino · 2011 · ChemBioChem
22. Photoinduced Intramolecular Macrocyclization Reaction between a Bpa and a Met Residue in a Helical Peptide: 3D Structures of the Diastereomeric Products
    Alessandro Moretto, Marco Crisma, Fernando Formaggio · 2008 · Chemistry - A European Journal
23. HBx-Derived Constrained Peptides Inhibit the Secretion of Hepatitis B Virus Antigens
    Xiaodan Cai, Weihao Zheng, Xiaodong Shi, Longjian Chen, Zhihong Liu, Zigang Li · 2018 · Molecular Pharmaceutics
24. hDM2 protein-binding peptides screened from stapled α-helical peptide phage display libraries with different types of staple linkers
    Teerapat Anananuchatkul, Hiroshi Tsutsumi, Takayuki Miki, Hisakazu Mihara · 2020 · Bioorganic & Medicinal Chemistry Letters
25. Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation
    Ewa D. Micewicz, Shantanu K. Sharma, Alan J. Waring, Hai T. Luong, William H. McBride, Piotr P. Ruchala · 2015 · International Journal of Peptide Research and Therapeutics
26. Stapled peptides as potential therapeutics for diabetes and other metabolic diseases
    Dominika Nielipinska, Dominika Rubiak, Agnieszka J. Pietrzyk‐Brzezinska, Joanna Małolepsza, K. M. Błażewska, Edyta Gendaszewska‐Darmach · 2024 · Biomedicine & Pharmacotherapy
27. Twisted Structure of a Cyclic Hexapeptide Containing a Combination of Alternating l -Leu- d -Leu-Aib Segments
    Yosuke Demizu, Saori Nagoya, Mitsunobu Doi · 2012 · The Journal of Organic Chemistry
28. Assembly of Complex Macrocycles by Incrementally Amalgamating Unprotected Peptides with a Designed Four-Armed Insert
    Brice H. Curtin, Francesco Manoni, Jiyong Park · 2018 · The Journal of Organic Chemistry
29. Long-range PEG stapling: macrocyclization for increased protein conformational stability and resistance to proteolysis
    Qiang Xiao, Dallin S. Ashton, Zachary B. Jones, Katherine P. Thompson, Joshua L. Price · 2020 · RSC Chemical Biology
30. An enhanced functional interrogation/manipulation of intracellular signaling pathways with the peptide ‘stapling’ technology
    Yuan He, David X. W. Chen, Weiping Zheng · 2015 · Oncogene
31. Coiled-Coil Domains for Self-Assembly and Sensitivity Enhancement of Protein–Polymer Conjugate Biosensors
    Justin M. Paloni, Bradley D. Olsen · 2020 · ACS Applied Polymer Materials
32. Design, synthesis, structure and properties of an α-helix cap template derived from N-[(2S)-2-chloropropionyl]-(2S)-Pro-(2R)-Ala-(2S,4S)-4-thioPro-OMe which initiates α-helical structures
    David Gani, Arwel Lewis, Trevor J. Rutherford, John S. Wilkie, Iain R. Stirling, Thierry Jenn, Martin D. Ryan · 1998 · Tetrahedron
33. Peptide Stapling with Boronate Esters‐ A Reversible Folding of (Artificial) Peptide Chain to α‐Helix
    Monika Kijewska, Grzegorz Wołczański, Marta Światowska, Katarzyna M. Kedziora, Miłosz Pawlicki, Piotr Stefanowicz · 2023 · Chemistry - A European Journal
34. Tightening up the structure, lighting up the pathway: application of molecular constraints and light to manipulate protein folding, self-assembly and function
    Beatrice N. Markiewicz, Robert M. Culik, Feng Gai · 2014 · Science China Chemistry
35. Design, synthesis, and biophysical properties of a helical Aβ1–42 analog: Inhibition of fibrillogenesis and cytotoxicity
    Katsumi Matsuzaki, Takuma Okada, Miho Tsukuda, Keisuke Ikeda, Youhei Sohma, Yousuke Chiyomori, Atsuhiko Taniguchi, Setsuko Nakamura, Nui Ito, Yoshio Hayashi et al. · 2008 · Biochemical and Biophysical Research Communications
36. Macrocyclic α-Helical Peptide Drug Discovery
    Tomi K. Sawyer, Vincent Guerlavais, Krzysztof Darłak, Eric Feyfant · 2014 · Royal Society of Chemistry eBooks
37. Reversibly switching the conformation of short peptide through in-tether chiral sulfonium auxiliary
    Xiaodong Shi, Yixiang Jiang, Dan Yang, Hui Zhao, Yuan Tian, Zigang Li · 2017 · Chinese Chemical Letters
38. Fluorogenically Active Leucine Zipper Peptides as Tag–Probe Pairs for Protein Imaging in Living Cells
    Hiroshi Tsutsumi, Wataru Nomura, Seiichiro Abe et al. · 2009 · Angewandte Chemie
39. Efficient synthesis of metal binding peptides incorporating aminodiacetic acid based ligands
    Wieslaw M. Kazmierski · 1995 · International journal of peptide & protein research
40. Helical Stabilization of Peptide Macrocycles by Stapled Architectures
    Fenfang Yang, Feng Yin, Zigang Li · 2021 · Methods in molecular biology
41. Peptide stapling by late-stage Suzuki–Miyaura cross-coupling
    Hendrik Gruß, Rebecca C. Feiner, Ridhiwan Mseya · 2022 · Beilstein Journal of Organic Chemistry
42. Comparison of Oct-2-enyl and Oct-4-enyl Staples for Their Formation and α-Helix Stabilizing Effects
    Thanh K. Pham, Jiyeon Yoo, Young‐Woo Kim · 2013 · Bulletin of the Korean Chemical Society
43. Functional stapled fragments of human preptin of minimised length
    Marta Lubos, Lucie Mrázková, Petra Gwozdiaková · 2022 · Organic & Biomolecular Chemistry
44. Synthesis of a symmetrically branched template for parallel α-helix dimers
    Frank Bambino, Robert T. C. Brownlee, Francis C. K. Chiu · 1994 · Tetrahedron Letters
45. Zinc(II)-mediated enhancement of the agonist activity of histidine-substituted parathyroid hormone(1–14) analogues
    Percy H. Carter, Thomas James Gardella · 2001 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
46. Main methods and tools for peptide development based on protein-protein interactions (PPIs)
    Baeza, Javiera, Bedoya, Mauricio, Cruz, Pablo, Ojeda, Paola, Adasme-Carreño, Francisco, Cerda, Oscar, González, Wendy · 2025 · Biochemical and Biophysical Research Communications
47. Structural guidelines for stabilization of α-helical coiled coils via PEG stapling
    Qiang Xiao, Zachary B. Jones, Samantha C. Hatfield, Dallin S. Ashton, Nicholas A. Dalley, Cody D. Dyer, Judah L. Evangelista, Joshua L. Price · 2022 · RSC Chemical Biology
48. Development of stapled helical peptides to perturb the Cdt1–Mcm6 interaction
    Jonghan Peter Lee, Changdong Liu, Tianlu Li, Guang Zhu, Xuechen Li · 2015 · Journal of Peptide Science
49. Engineering of biomolecules for sensing and imaging applications
    Sébastien Ulrich, Pascal Dumy, Didier Boturyn, Olivier Renaudet · 2013 · Journal of Drug Delivery Science and Technology
50. A Method to Calculate the Relative Binding Free Energy Differences of α-Helical Stapled Peptides
    Pedro Alberto Valiente, David Becerra, Philip M. Kim · 2020 · The Journal of Organic Chemistry
51. Synthesis of homologs of cysteine suitable for peptide and protein crosslinking
    Ray Lutgring, K. Sujatha, Jean A. Chmielewski · 1993 · Bioorganic & Medicinal Chemistry Letters
52. Receptor-templated stapling of intrinsically disordered peptide ligands
    Conor M. Haney, W. Seth Horne · 2015 · Organic & Biomolecular Chemistry
53. Helix–Coil Transition at a Glycine Following a Nascent α-Helix: A Synergetic Guidance Mechanism for Helix Growth
    Sunit Pal, Shreya Banerjee, Erode N. Prabhakaran · 2020 · The Journal of Physical Chemistry A
54. Rational Design Strategies for Developing Synthetic Inhibitors of Helical Protein Interfaces
    Andrew B. Mahon, Stephen E. Miller, Stephen T. Joy, Paramjit S. Arora · 2012 · Topics in medicinal chemistry
55. Synthetic α‐helical peptides incorporating intercalators for DNA recognition
    Christopher L. Brown, Margaret M. Harding · 1994 · Journal of Molecular Recognition
56. Synthesis of protected ω-mercapto amino acids: precursors for incorporation of elongated cysteines into peptides
    Joseph T. IV Lundquist, Erika E. Büllesbach, Thomas A. Dix · 1998 · Tetrahedron Asymmetry
57. The 1,3‐diyne linker as a rigid “ i , i +7” staple for α‐helix stabilization: Stereochemistry at work
    Steven Verlinden, Niels Geudens, Kevin Van holsbeeck, Morgane Mannes, José C. Martins, Guido Verniest, Steven Ballet · 2019 · Journal of Peptide Science
58. Short Oligourea Foldamers as N‐ or C‐Caps for Promoting α‐Helix Formation in Water
    Laura Mauran, Coralie Assailly, Sébastien R. Goudreau, Benoı̂t Odaert, Gilles Guichard, Morgane Pasco · 2024 · ChemBioChem
59. Backbone distortions in lactam‐bridged helical peptides
    Ali Moazzam, Vesna Stanojlović, Arthur Hinterholzer · 2022 · Journal of Peptide Science
60. The B domain of protein A retains residual structures in 6 M guanidinium chloride as revealed by hydrogen/deuterium‐exchange NMR spectroscopy
    Saeko Yanaka, Maho Yagi‐Utsumi, Koichi Kato, Kunihiro Kuwajima · 2023 · Protein Science
61. Hierarchical Self-Assembled Peptide Nano-ensembles
    Priyadharshini Kumaraswamy, Swaminathan Sethuraman, Jatinder Vir Yakhmi · 2014 · Springer eBooks
62. Trimodular Solution‐Phase Protocol for Rapid Large‐Scale Synthesis of Hydrogen Bond Surrogate‐Constrained α‐Helicomimics
    Sunit Pal, Erode N. Prabhakaran · 2021 · European Journal of Organic Chemistry
63. Synthesis of enantiomerically pure N-Fmoc-S-Mob-(S)-α-Amino-ε-mercaptohexanoic acid and its use in solid phase peptide synthesis
    Norbert V. Heeb, Alfred M. Aberle, Krishnan P. Nambiar · 1994 · Tetrahedron Letters
64. Examination of the Effect of N‐terminal Diproline and Charged Side Chains on the Stabilization of Helical Conformation in Alanine–based Short Peptides: A Molecular Dynamics Study
    Bhupesh Goyal, Kinshuk Raj Srivastava, Susheel Durani · 2016 · ChemistrySelect
65. Parallel Temperature Replica-Exchange Molecular Dynamics Simulations Capture the Observed Impact of Stapling on Coiled-Coil Conformational Stability
    Joshua L. Price · 2025 · The Journal of Physical Chemistry B
66. Synthesis of lactam-bridged cyclic peptides using sequential olefin metathesis and diimide reduction reactions
    Keisuke Aihara, Tsubasa Inokuma, Chiaki Komiya, Akira Shigenaga, Akira Otaka · 2015 · Tetrahedron
67. Impact of Hydrogen‐Bond Surrogate Model on Helix Stabilization and Development of Protein‐Protein Interaction Inhibitors
    Sunit Pal · 2023 · ChemistrySelect
68. Redox‐Triggered Reversible Switching between Dynamic and Quasi‐static α‐Helical Peptides
    Naoki Ousaka, Mark J. MacLachlan, Shigehisa Akine · 2024 · Chemistry - A European Journal
69. Mechanische Verstärkung von Coiled Coils mit Lactam und Histidin‐Metall‐Klammern
    Patricia López‐García, A. D. de Araujo, A. E. Bergues-Pupo, Isabell Tunn, David P. Fairlie, Kerstin Blank · 2020 · Angewandte Chemie
70. Peptidchemie 1991: Ein Jahr der Grenzüberwindung?
    Manfred Mutter · 1992 · Nachrichten aus Chemie Technik und Laboratorium
71. Coulombic and noncoulombic effect of polyanions on cytochrome c structure
    Erik Sedlák, Marián Antalı́k · 1998 · Biopolymers
72. Discovery of Peptide Drugs from Natural Sources
    Sónia Troeira Henriques, David J. Craik · 2015 · Wiley eBooks
73. Impact of the amino acid sequence on the conformation of side chain lactam‐bridged octapeptides
    Saskia Neukirchen, Viktoria Krieger, Cornelia Roschger, Mario Schubert, Brigitta Elsässer, Chiara Cabrele · 2017 · Journal of Peptide Science
74. Constraining and Modifying Peptides Using Pd‐Mediated Cysteine Allylation
    Julia Kriegesmann, Thomas Schlatzer, Kateryna Che, Claudia Altdorf, Susanne Huhmann, Hanspeter Kählig, Dennis Kurzbach, Rolf Breinbauer, Christian F. W. Becker · 2023 · ChemBioChem
75. Engineered Disulfide Bonds for Protein Design
    Luis Moroder, H.‐J. Musiol, Christian Renner · 2008 · Royal Society of Chemistry eBooks
76. De NovoDesign of Proteins
    Knud J. Jensen · 2009
77. Design and Synthesis of Cyclic Peptide Antagonists Intended to Block Coactivator Binding to Steroid Nuclear Receptors
    Anne‐Marie Leduc, Kelli S. Bramlett, Thomas P. Burris · 2001 · Springer eBooks
78. Peptidomimetics of α‐Helical and β‐Strand Protein Binding Epitopes
    Nina Bionda, Rudi Fasan · 2015 · Wiley eBooks
79. Design of Emulsification Peptides
    David Sheehan, Kathleen Carey, Siobhán O’Sullivan · 1998 · Advances in food and nutrition research
80. Stapled Peptides as Potential Therapeutics
    Laura McDougall, Andrew G. Jamieson · 2019 · Wiley eBooks
81. The role of multivalency in the association of the eight twenty-one protein 2 (ETO2) with the nucleosome remodeling and deacetylase (NuRD) complex
    Glory Dan-Dukor, Shengzhe Shang, Gage O. Leighton, Christopher R. Travis, Timothy D. Schwochert, Parnika Agrawal, Oyindamola Ajasa, Torry Li, Marcey L. Waters, Gordon D. Ginder et al. · 2025 · Nucleic Acids Research
82. Trifluoroacetic Acid Promotes Ultrafast Peptide Cyclization Mediated with Dimethylolurea
    Shi Wang, Huanhuan Yang, Jinlin Song et al. · 2025 · Organic Letters
83. Design and Stability of α‐Helices
    Andrew J. Doig, Neil Errington, Teuku M. Iqbalsyah · 2008 · Protein Science Encyclopedia
84. De novo design of semisynthetic protein nanopores
    Lee Schnaider, A. Katherine Hatstat, Alistair J. Scott et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
85. Ferrocene Constrained Helical Peptides via On-Resin Cyclization
    T. Andrew McTeague · 2012
86. Dynamic Covalent Capture: A Sensitive Tool for Detecting Molecular Interactions
    Leonard J. Prins · 2010 · Wiley eBooks
87. Targeting alpha-helix based protein interactions; nuclear receptors as a case study
    L.‐G. Milroy, Lidia Nieto, Luc Brunsveld · 2012 · Royal Society of Chemistry eBooks
88. The Stabilizing Effects ofO-glycosylation on the Secondary Structural Integrity of the Designed α-loop-α motif by Molecular Dynamics Simulations
    Hsuan‐Liang Liu, Chiao-Kai Hwang, Jin‐Chung Lin · 2004 · Journal of Biomolecular Structure and Dynamics
89. 17 The protein epitope mimetic approach to protein-protein interaction inhibitors
    John A. Robinson, Kerstin Moehle · 2011 · De Gruyter eBooks
90. Discovery and characterization of novel cysteine-rich peptides in medicinal plants
    Wei Liang Tan · 2018
91. Molecular Imaging Agent Design for Quantifying Beta Cell Mass in Type 1 Diabetes
    Liang Zhang · 2017 · Deep Blue (University of Michigan)
92. Effects of chiral center on an all‐hydrocarbon tethered peptide
    Xiaodong Shi, Kuan Hu, Hao Ran Geng, Zhihong Liu, Feng Yin, Zigang Li · 2018 · Peptide Science
93. Bisthioether Stapled Peptides Targeting Polycomb Repressive Complex 2 Gene Repression
    Gan Zhang · 2019 · CUNY Academic Works (City University of New York)
94. Interface Peptides
    Mark W. Peczuh, Richard T. Desmond · 2010
95. Classes, Modes of Action and Selection of New Modalities in Drug Discovery
    Eric Valeur · 2020 · Royal Society of Chemistry eBooks
96. Synthesis and Structural Stability of α-Helical Gold(I)-Metallopeptidesy
    Pol Besenius, Lydia Zengerling, Benedict Kemper, Ute A. Hellmich · 2020 · Synlett
97. Helix-mimetics as Protein–Protein Interaction Inhibitors
    Gitashri Naiya, Madhumita Chakraborty, Piya Ghosh, Siddhartha Roy · 2020 · Royal Society of Chemistry eBooks
98. Hydrogen Bond Surrogate Stabilized Helices as Protein–Protein Interaction Inhibitors
    Daniel Y. Yoo, Paramjit S. Arora · 2020 · Royal Society of Chemistry eBooks
99. Synthesis of In-Tether Chiral Center Peptides and Their Biophysical Properties Study
    Kuan Hu · 2021 · Springer theses
100. Large Scale Synthesis of Native Turn and Helix Mimics Stabilized by a Generic Hydrogen Bond Surrogate
     Erode N. Prabhakaran, Sunit Pal, Ankur Kumar · 2021 · Research Square