Extremely Large Isotope Effects in the Soybean Lipoxygenase-Linoleic Acid Reaction
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExtremely Large Isotope Effects in the Soybean Lipoxygenase-Linoleic Acid ReactionMichael H. Glickman, Jeffrey S. Wiseman, and Judith P. KlinmanCite this: J. Am. Chem. Soc. 1994, 116, 2, 793–794Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/ja00081a060https://doi.org/10.1021/ja00081a060research-articleACS PublicationsRequest reuse permissionsArticle Views524Altmetric-Citations141LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmai…
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In wild-type soybean lipoxygenase, a high kinetic isotope effect of approximately 80 has been experimentally observed and verified using theory.
“Furthermore, in a proton transfer reaction catalysed by enzyme soybean lipoxygenase, in the wild type, a high KIE of ~80 41 has been experimentally observed and verified using theory 42 .”
From An open quantum systems approach to proton tunnelling in DNA (2022) · cites this paper as [41]
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Huynh, M. H. V., & Meyer, T. J. (2007) · Chemical Reviews · doi:10.1021/cr0500030 · Cited by 1,659 · see citing works
An open quantum systems approach to proton tunnelling in DNA
Slocombe, L., Sacchi, M., & Al-Khalili, J. (2022) · Communications Physics · doi:10.1038/s42005-022-00881-8 · Cited by 122 · see citing works
Choreographing an enzyme's dance
Villali, J., & Kern, D. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2010.08.007 · Cited by 98 · see citing works
- Authors
- Glickman, M. H., Wiseman, J. S., & Klinman, J. P.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 1994-01
- Volume
- 116
- Issue
- 2
- Pages
- 793-794
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2016201075
- Cited by
- 161
- References
- 0
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 6 · 2018: 2 · 2017: 7 · 2016: 1 · 2015: 2 · 2014: 8 · 2013: 4 · 2012: 4
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Chemical Society (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Chemical Reaction Mechanisms
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
- Physical Sciences › Chemistry › Organic Chemistry › Oxidative Organic Chemistry Reactions
- Keywords
- isotope effects, soybean lipoxygenase, linoleic acid, oxygen-18 isotope effect, oxygen atom transfer, enzyme mechanism, fatty acid oxidation
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