Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteinsRichard D. Cramer, David E. Patterson, and Jeffrey D. BunceCite this: J. Am. Chem. Soc. 1988, 110, 18, 5959–5967Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://pubs.acs.org/doi/10.1021/ja00226a005https://doi.org/10.1021/ja00226a005research-articleACS PublicationsRequest reuse permissionsArticle Views4288Altmetric-Citations3342LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
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Comparative Molecular Field Analysis (CoMFA) was extremely successful because of its visual appeal, making clear where and how to modify a molecule to increase its activity.
“Comparative Molecular Field Analysis (CoMFA)42 was extremely successful because of its visual appeal – it was clear where and how to modify a molecule to increase its activity.”
From QSAR without borders (2020) · cites this paper as [42]
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- Authors
- Cramer, R. D., Patterson, D. E., & Bunce, J. D.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 1988-08
- Volume
- 110
- Issue
- 18
- Pages
- 5959-5967
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2063060349
- Cited by
- 3,931
- References
- 0
- Citations by year
- 2026: 31 · 2025: 44 · 2024: 59 · 2023: 68 · 2022: 78 · 2021: 102 · 2020: 88 · 2019: 112 · 2018: 121 · 2017: 122 · 2016: 125 · 2015: 142 · 2014: 141 · 2013: 164 · 2012: 178
- FWCI
- 16.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Chemical Society (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- CoMFA, steroid binding, carrier proteins, molecular geometry, steroid-protein binding, molecular shape effects
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