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Efficient Mixing and Reactions within Microfluidic Channels Using Microbead-Supported Catalysts
Abstract
A strategy for efficiently mixing solutions and carrying out multistep catalytic reactions in microfluidic systems is described. The approach involves immobilizing catalysts on microbeads, placing the beads into well-defined microreactor zones, and then passing reactants through one or more of the reactor zones to yield products. The catalyst-modified beads effectively mix reactants and increase the effective surface area of the channel interior, both of which improve reaction velocities compared to open channels. This approach is demonstrated using two sequential reactions catalyzed by glucose oxidase and horseradish peroxidase. In addition to providing a general route to chemical synthesis within microfluidic systems, this design strategy may also be applicable to modeling reaction pathways within cells and to bio/chemical sensing applications.
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Cited by
Microfluidics: Fluid physics at the nanoliter scale
Squires, T. M., & Quake, S. R. (2005) · Reviews of Modern Physics · doi:10.1103/revmodphys.77.977 · Cited by 4,379
Microfluidic devices fabricated in Poly(dimethylsiloxane) for biological studies
Sia, S. K., & Whitesides, G. M. (2003) · ELECTROPHORESIS · doi:10.1002/elps.200305584 · Cited by 1,717
Flash chemistry: flow chemistry that cannot be done in batch
Yoshida, J.-I., Takahashi, Y., & Nagaki, A. (2013) · Chem. Commun. · doi:10.1039/c3cc44709j · Cited by 450
Synthesis of Silver Nanoparticles in a Continuous Flow Tubular Microreactor
Lin, X. Z., Terepka, A. D., & Yang, H. (2004) · Nano Letters · doi:10.1021/nl0485859 · Cited by 272
Permeation-driven flow in poly(dimethylsiloxane) microfluidic devices.
Randall, G. C., & Doyle, P. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503287102 · Cited by 220
Metadata
- Authors
- Seong, G. H., & Crooks, R. M.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-10-17
- Volume
- 124
- Issue
- 45
- Pages
- 13360-13361
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2075774196
- Cited by
- 193
- References
- 0
- FWCI
- 16.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Seong, G. H., & Crooks, R. M. (2002). Efficient Mixing and Reactions within Microfluidic Channels Using Microbead-Supported Catalysts. Journal of the American Chemical Society. https://doi.org/10.1021/ja020932y
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
