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Microfluidic devices fabricated in Poly(dimethylsiloxane) for biological studies
Abstract
This review describes microfluidic systems in poly(dimethylsiloxane) (PDMS) for biological studies. Properties of PDMS that make it a suitable platform for miniaturized biological studies, techniques for fabricating PDMS microstructures, and methods for controlling fluid flow in microchannels are discussed. Biological procedures that have been miniaturized into PDMS‐based microdevices include immunoassays, separation of proteins and DNA, sorting and manipulation of cells, studies of cells in microchannels exposed to laminar flows of fluids, and large‐scale, combinatorial screening. The review emphasizes the advantages of miniaturization for biological analysis, such as efficiency of the device and special insights into cell biology.
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Cited by
The origins and the future of microfluidics
Whitesides, G. M. (2006) · Nature · doi:10.1038/nature05058 · Cited by 9,687
Self-citationMicrofluidic lab-on-a-chip platforms: requirements, characteristics and applications
Mark, D., Haeberle, S., Roth, G., von Stetten, F., & Zengerle, R. (2010) · Chemical Society Reviews · doi:10.1039/b820557b · Cited by 1,647
Seemann, R., Brinkmann, M., Pfohl, T., & Herminghaus, S. (2012) · Reports on Progress in Physics · doi:10.1088/0034-4885/75/1/016601 · Cited by 1,049
Au, A. K., Huynh, W., Horowitz, L. F., & Folch, A. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201504382 · Cited by 788
Low-Cost Printing of Poly(dimethylsiloxane) Barriers To Define Microchannels in Paper
Bruzewicz, D. A., Reches, M., & Whitesides, G. M. (2008) · Analytical Chemistry · doi:10.1021/ac702605a · Cited by 616
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Metadata
- Authors
- Sia, S. K., & Whitesides, G. M.
- Venue
- ELECTROPHORESIS
- Publisher
- Wiley
- Published
- 2003-11
- Volume
- 24
- Issue
- 21
- Pages
- 3563-3576
- ISSN
- 0173-0835 (ISSN-L)
- 1522-2683
- OpenAlex
- W2124918094
- Cited by
- 1,717
- References
- 0
- FWCI
- 34.33
- Type
- journal article
- Language
- en
- Open access
- closed
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