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A Modular Cross-Linking Approach for Exploring Protein Interactions
Abstract
A method is described for the elucidation of protein-protein interactions using novel cross-linking reagents and mass spectrometry. The method incorporates (1) a modular solid-phase synthetic strategy for generating the cross-linking reagents, (2) enrichment and digestion of cross-linked proteins using microconcentrators, (3) mass spectrometric analysis of cross-linked peptides, and (4) comprehensive computational analysis of the cross-linking data. This integrated approach has been applied to the study of cross-linking between the components of the heterodimeric protein complex negative cofactor 2.
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Citations
Cited by
Sinz, A. (2006) · Mass Spectrometry Reviews · doi:10.1002/mas.20082 · Cited by 648
Probing Native Protein Structures by Chemical Cross-linking, Mass Spectrometry, and Bioinformatics
Leitner, A., Walzthoeni, T., Kahraman, A., Herzog, F., Rinner, O., Beck, M., & Aebersold, R. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r000001-mcp201 · Cited by 458
Chen, H.-T., Neerman, M. F., Parrish, A. R., & Simanek, E. E. (2004) · Journal of the American Chemical Society · doi:10.1021/ja048548j · Cited by 411
Protein Complexes in the Gas Phase: Technology for Structural Genomics and Proteomics
Benesch, J. L. P., Ruotolo, B. T., Simmons, D. A., & Robinson, C. V. (2007) · Chemical Reviews · doi:10.1021/cr068289b · Cited by 408
Leitner, A., Faini, M., Stengel, F., & Aebersold, R. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.10.008 · Cited by 355
Metadata
- Authors
- Trester-Zedlitz, M., Kamada, K., Burley, S. K., Fenyö, D., Chait, B. T., & Muir, T. W.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-02-06
- Volume
- 125
- Issue
- 9
- Pages
- 2416-2425
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1997874752
- Cited by
- 195
- References
- 0
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Trester-Zedlitz, M., Kamada, K., Burley, S. K., Fenyö, D., Chait, B. T., & Muir, T. W. (2003). A Modular Cross-Linking Approach for Exploring Protein Interactions. Journal of the American Chemical Society. https://doi.org/10.1021/ja026917a
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
