The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Designing Macromolecules for Therapeutic Applications: Polyester DendrimerPoly(ethylene oxide) “Bow-Tie” Hybrids with Tunable Molecular Weight and Architecture
Abstract
The design and preparation of new polyester dendrimer, poly(ethylene oxide) hybrid systems for drug delivery and related therapeutic applications, are described. These systems consist of two covalently attached polyester dendrons, where one dendron provides multiple functional handles for the attachment of therapeutically active moieties, while the other is used for attachment of solubilizing poly(ethylene oxide) chains. By varying the generation of the dendrons and the mass of the poly(ethylene oxide) chains, the molecular weight, architecture, and drug loading can be readily controlled. The "bow-tie" shaped dendritic scaffold was synthesized using both convergent and divergent methods, with orthogonal protecting groups on the periphery of the two dendrons. Poly(ethylene oxide) was then attached to the periphery of one dendron using an efficient coupling procedure. A small library of eight carriers with molecular weights ranging from about 20 kDa to 160 kDa were prepared and characterized by various techniques, confirming their well-defined structures.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Polyester Dendritic Systems for Drug Delivery Applications: In Vitro and In Vivo Evaluation
Padilla De Jesús, O. L., Ihre, H. R., Gagne, L., Fréchet, J. M. J., & Szoka, F. C. (2002) · Bioconjugate Chemistry · doi:10.1021/bc010103m · Cited by 507
Self-citation
Cited by
Cancer nanotechnology: opportunities and challenges
Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558
Dendrimers in biomedical applications—reflections on the field
SVENSON, S., & TOMALIA, D. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.09.018 · Cited by 1,919
Dendrimers in Oncology: An Expanding Horizon
Tekade, R. K., Kumar, P. V., & Jain, N. K. (2009) · Chemical Reviews · doi:10.1021/cr068212n · Cited by 466
Simplifying the synthesis of dendrimers: accelerated approaches
Walter, M. V., & Malkoch, M. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35062a · Cited by 301
Dendrimeric micelles for controlled drug release and targeted delivery
Ambade, A. V., Savariar, E. N., & Thayumanavan, S. (2005) · Molecular Pharmaceutics · doi:10.1021/mp050020d · Cited by 245
Metadata
- Authors
- Gillies, E. R., & Fréchet, J. M. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-11-01
- Volume
- 124
- Issue
- 47
- Pages
- 14137-14146
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2014354647
- Cited by
- 328
- References
- 1
- FWCI
- 17.09
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Designing Macromolecules for Therapeutic Applications: Polyester DendrimerPoly(ethylene oxide) “Bow-Tie” Hybrids with Tunable Molecular Weight and Architecture. https://app.cochat.ai/papers/10.1021/ja028100n
- The paper
- Gillies, E. R., & Fréchet, J. M. J. (2002). Designing Macromolecules for Therapeutic Applications: Polyester DendrimerPoly(ethylene oxide) “Bow-Tie” Hybrids with Tunable Molecular Weight and Architecture. Journal of the American Chemical Society. https://doi.org/10.1021/ja028100n
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
