The DOI matches its Crossref record.
Structure of the First Parallel DNA Quadruplex-Drug Complex
Abstract
The first crystal structure of a drug (daunomycin) bound to a parallel-stranded intermolecular telomeric G4 quadruplex (d(TGGGGT)4) has been determined to high resolution. A planar assemblage of three daunomycin molecules stacks onto the 5' end of the G4 column, with the daunosamine substituents occupying three of the four quadruplex grooves. The surface area of the terminal G-quartet in this parallel DNA quadruplex, presently occupied by three daunomycins, is sufficiently large that it could easily accommodate other potential telomerase inhibitors such as substituted porphyrins or telomestatin.
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Cited by
G‐Quartets 40 Years Later: From 5′‐GMP to Molecular Biology and Supramolecular Chemistry
Davis, J. T. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200300589 · Cited by 1,626
The Structure and Function of DNA G-Quadruplexes
Spiegel, J., Adhikari, S., & Balasubramanian, S. (2020) · Trends in Chemistry · doi:10.1016/j.trechm.2019.07.002 · Cited by 920
“An X-ray structure of the small molecule daunomycin in complex with the G4 formed by four strands of d(TGGGGT) confirmed stacking of small molecules on a terminal G-quartet [26].”
BackgroundInfluentialA hitchhiker's guide to G-quadruplex ligands
Monchaud, D., & Teulade-Fichou, M.-P. (2008) · Org. Biomol. Chem. · doi:10.1039/b714772b · Cited by 788
The structures of quadruplex nucleic acids and their drug complexes
Neidle, S. (2009) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2009.04.001 · Cited by 433
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Metadata
- Authors
- Clark, G. R., Pytel, P. D., Squire, C. J., & Neidle, S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-03-15
- Volume
- 125
- Issue
- 14
- Pages
- 4066-4067
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2005307841
- Cited by
- 212
- References
- 0
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Clark, G. R., Pytel, P. D., Squire, C. J., & Neidle, S. (2003). Structure of the First Parallel DNA Quadruplex-Drug Complex. Journal of the American Chemical Society. https://doi.org/10.1021/ja0297988
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