The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Ultrasensitive Electrical Biosensing of Proteins and DNA: Carbon-Nanotube Derived Amplification of the Recognition and Transduction Events
Abstract
A new strategy for dramatically amplifying enzyme-linked electrical detection of proteins and DNA using carbon nanotubes (CNTs) for carrying numerous enzyme tracers and accumulating the enzymatically liberated product on CNT-modified transducer is described. Such a CNT-derived double-step amplification pathway (of both the recognition and transduction events) allows the detection of DNA and proteins down to 1.3 and 160 zmol, respectively, in 25-50 muL samples and indicates great promise for PCR-free DNA analysis. The new protocol is illustrated for monitoring sandwich hybridization and antibody-antigen interactions in connection with alkaline-phosphatase tracers. The DNA-linking of CNTs and particles holds promise also for assembling hybrid nanostructures relevant to molecular electronic devices.
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Drummond, T. G., Hill, M. G., & Barton, J. K. (2003) · Nature Biotechnology · doi:10.1038/nbt873 · Cited by 2,214
Cited by
Nanostructures in Biodiagnostics
Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
Carbon‐Nanotube Based Electrochemical Biosensors: A Review
Wang, J. (2005) · Electroanalysis · doi:10.1002/elan.200403113 · Cited by 2,387
Self-citationNanotechnology applications in cancer
Nie, S., Xing, Y., Kim, G. J., & Simons, J. W. (2007) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.9.060906.152025 · Cited by 952
Electrochemical Immunosensors for Detection of Cancer Protein Biomarkers
Chikkaveeraiah, B. V., Bhirde, A. A., Morgan, N. Y., Eden, H. S., & Chen, X. (2012) · ACS Nano · doi:10.1021/nn3023969 · Cited by 719
Electrochemistry of Nucleic Acids
Paleček, E., & Bartošík, M. (2012) · Chemical Reviews · doi:10.1021/cr200303p · Cited by 668
Metadata
- Authors
- Wang, J., Liu, G., & Jan, M. R.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-02-18
- Volume
- 126
- Issue
- 10
- Pages
- 3010-3011
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2087031607
- Cited by
- 682
- References
- 1
- FWCI
- 41.85
- Type
- journal article
- Language
- en
- Open access
- closed
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