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Base-Dependent Competitive Adsorption of Single-Stranded DNA on Gold

Kimura-Suda, Hiromi, Petrovykh, Dmitri Y., Tarlov, Michael J., Whitman, Lloyd J.·2003·Journal of the American Chemical Society

Abstract

We characterize the room-temperature adsorption of single-stranded DNA homo-oligonucleotides from solution onto polycrystalline Au films, including competitive adsorption between all possible pairs of unmodified oligomers. Fourier transform infrared (FTIR) and X-ray photoelectron (XPS) spectroscopy analysis of the resulting films shows that oligonucleotides adsorb with a strongly base-dependent affinity, adenine (A) > cytosine (C) >/= guanine (G) > thymine (T). In competitive adsorption experiments on Au, oligo(dA) strongly dominates over the other oligonucleotides. The relative adsorption affinity of oligo(dA) is so great that it competes effectively against adsorption of thiolated oligomers and even causes hybridized oligo(dA).oligo(dT) duplexes to denature in the presence of Au.

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Metadata

Authors
Kimura-Suda, H., Petrovykh, D. Y., Tarlov, M. J., & Whitman, L. J.
Venue
Journal of the American Chemical Society
Published
2003-07-01
Volume
125
Issue
30
Pages
9014-9015
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
OpenAlex
W2053014859
Cited by
488
References
0
FWCI
3.22
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Base-Dependent Competitive Adsorption of Single-Stranded DNA on Gold. https://app.cochat.ai/papers/10.1021/ja035756n
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Kimura-Suda, H., Petrovykh, D. Y., Tarlov, M. J., & Whitman, L. J. (2003). Base-Dependent Competitive Adsorption of Single-Stranded DNA on Gold. Journal of the American Chemical Society. https://doi.org/10.1021/ja035756n

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