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Gatekeeping Layer Effect: A Poly(lactic acid)-coated Mesoporous Silica Nanosphere-Based Fluorescence Probe for Detection of Amino-Containing Neurotransmitters
Abstract
We have synthesized a poly(lactic acid) coated MCM-41-type mesoporous silica nanosphere (PLA-MSN) material can serve as a fluorescence sensor system for detection of amino-containing neurotransmitters in neutral aqueous buffer. Utilizing the PLA layer as a gatekeeper, we investigated the molecular recognition events between several structurally simple neurotransmitters, i.e., dopamine, tyrosine, and glutamic acid and a pore surface-anchored o-phthalic hemithioacetal (OPTA) group, which functions as a fluorescence-sensing group that can react with the neurotransmitters with primary amine groups and form the corresponding fluorescent isoindole products. The poly(lactic acid) layer of the PLA-MSN sensor showed a unique "sieving" effect that regulates the rates of diffusion of the amino acid-based neurotransmitters into the sensor mesopores of the material.
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Cited by
Mesoporous silica nanoparticles for drug delivery and biosensing applications
Slowing, I. I., Trewyn, B. G., Giri, S., & Lin, V. S. ‐. (2007) · Advanced Functional Materials · doi:10.1002/adfm.200601191 · Cited by 1,699
Self-citationTrewyn, B. G., Slowing, I. I., Giri, S., Chen, H.-T., & Lin, V. S.-Y. (2007) · Accounts of Chemical Research · doi:10.1021/ar600032u · Cited by 1,123
Self-citationChallenges and breakthroughs in recent research on self-assembly
Ariga, K., Hill, J. P., Lee, M. V., Vinu, A., Charvet, R., & Acharya, S. (2008) · Science and Technology of Advanced Materials · doi:10.1088/1468-6996/9/1/014109 · Cited by 759
Porous Nanoparticle Supported Lipid Bilayers (Protocells) as Delivery Vehicles
Liu, J., Stace-Naughton, A., Jiang, X., & Brinker, C. J. (2009) · Journal of the American Chemical Society · doi:10.1021/ja808018y · Cited by 327
Metadata
- Authors
- Radu, D. R., Lai, C.-Y., Wiench, J. W., Pruski, M., & Lin, V. S.-Y.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-01-22
- Volume
- 126
- Issue
- 6
- Pages
- 1640-1641
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2001993030
- Cited by
- 230
- References
- 0
- FWCI
- 10.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Radu, D. R., Lai, C.-Y., Wiench, J. W., Pruski, M., & Lin, V. S.-Y. (2004). Gatekeeping Layer Effect: A Poly(lactic acid)-coated Mesoporous Silica Nanosphere-Based Fluorescence Probe for Detection of Amino-Containing Neurotransmitters. Journal of the American Chemical Society. https://doi.org/10.1021/ja038222v
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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