Mesoporous silica nanoparticles for drug delivery and biosensing applications
Abstract
Abstract Recent advancements in morphology control and surface functionalization of mesoporous silica nanoparticles (MSNs) have enhanced the biocompatibility of these materials with high surface areas and pore volumes. Several recent reports have demonstrated that the MSNs can be efficiently internalized by animal and plant cells. The functionalization of MSNs with organic moieties or other nanostructures brings controlled release and molecular recognition capabilities to these mesoporous materials for drug/gene delivery and sensing applications, respectively. Herein, we review recent research progress on the design of functional MSN materials with various mechanisms of controlled release, along with the ability to achieve zero release in the absence of stimuli, and the introduction of new characteristics to enable the use of nonselective molecules as screens for the construction of highly selective sensor systems.
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Porous materials present great value for applications in energy conversion and storage, catalysis, drug delivery, gas capture, and water purification.
“With these unique features, porous materials present great value for applications in energy conversion and storage [132,133,134,135], catalysis [136], drug delivery [137], gas capture [138,139], and water purification [140,141].”
From Block Copolymers: Synthesis, Self-Assembly, and Applications (2017) · cites this paper as [137]
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- Authors
- Slowing, I. I., Trewyn, B. G., Giri, S., & Lin, V. S. ‐.
- Affiliations
- Iowa State University (US)
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2007-04-20
- Volume
- 17
- Issue
- 8
- Pages
- 1225-1236
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2149183402
- Cited by
- 1,699
- References
- 64
- Citations by year
- 2026: 27 · 2025: 37 · 2024: 40 · 2023: 38 · 2022: 45 · 2021: 99 · 2020: 103 · 2019: 94 · 2018: 131 · 2017: 109 · 2016: 120 · 2015: 128 · 2014: 119 · 2013: 135 · 2012: 107
- FWCI
- 45.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Functional Materials (publishedVersion)
- Funders
- U.S. National Science Foundation (CHE-0239570)
- U.S. DOE Ames Laboratory (W-7405-Eng-82)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Mesoporous Materials and Catalysis
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Clay minerals and soil interactions
- Keywords
- mesoporous silica nanoparticles, drug delivery, gene delivery, biosensing, surface functionalization, controlled release, stimuli-responsive release, zero-order release, molecular recognition, biocompatibility, cellular internalization, morphology control
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