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Signal Amplification and Detection via a Supramolecular Allosteric Catalyst
Abstract
The design of a supramolecular allosteric catalyst system for catalytic signal amplification and detection is presented. The catalyst was switched "on" by the introduction of an analyte that also behaves as an allosteric activator. Concentrations of Cl- ions as low as 800 nM were catalytically amplified and detected. The signal was transduced via a pH-sensitive fluorescent probe and observed visually using a laboratory, handheld UV lamp and by spectrophotometry. Furthermore, the allosteric effect was quantified using gas chromatography for a range of Cl- concentrations. This three-part detection scheme involving analyte binding, allosteric catalyst activation, and signal transduction represents a new approach to small-molecule detection.
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Cited by
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Raynal, M., Ballester, P., Vidal-Ferran, A., & van Leeuwen, P. W. N. M. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60037h · Cited by 927
Development of a Coordination Chemistry-Based Approach for Functional Supramolecular Structures
Gianneschi, N. C., Masar, M. S., & Mirkin, C. A. (2005) · Accounts of Chemical Research · doi:10.1021/ar980101q · Cited by 554
Self-citationAllosteric Supramolecular Triple-Layer Catalysts
Yoon, H. J., Kuwabara, J., Kim, J.-H., & Mirkin, C. A. (2010) · Science · doi:10.1126/science.1193928 · Cited by 321
Self-citationMaterial Applications for Salen Frameworks
Wezenberg, S. J., & Kleij, A. W. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200702468 · Cited by 289
Signal Amplification by Allosteric Catalysis
Zhu, L., & Anslyn, E. V. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200501476 · Cited by 151
Metadata
- Authors
- Gianneschi, N. C., Nguyen, S. T., & Mirkin, C. A.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-01-22
- Volume
- 127
- Issue
- 6
- Pages
- 1644-1645
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2037313508
- Cited by
- 190
- References
- 0
- FWCI
- 10.32
- Type
- journal article
- Language
- en
- Open access
- closed
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