The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Loop-Length-Dependent Folding of G-Quadruplexes
Abstract
Guanine-rich DNA sequences can form a large number of structurally diverse quadruplexes. These vary in terms of strand polarity, loop composition, and conformation. We have derived guidelines for understanding the influence of loop length on the structure adopted by intramolecular quadruplex-forming sequences, using a combination of experimental (using CD and UV melting data) and molecular modeling and simulation techniques. We find that a parallel-stranded intramolecular quadruplex structure is the only possible fold when three single residue loops are present. When single thymine loops are present in combination with longer length loops, or when all loops are longer than two residues, both parallel- and antiparallel-folded structures are able to form. Multiple conformations of each structure are likely to coexist in solution, as they were calculated to have very similar free energies.
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Cites
Kollman, P. A., Massova, I., Reyes, C., Kuhn, B., Huo, S., Chong, L., Lee, M., Lee, T., Duan, Y., Wang, W., et al. (2000) · Accounts of Chemical Research · doi:10.1021/ar000033j · Cited by 4,978
Crystal structure of parallel quadruplexes from human telomeric DNA
Parkinson, G. N., Lee, M. P. H., & Neidle, S. (2002) · Nature · doi:10.1038/nature755 · Cited by 2,031
Self-citationHELIX FORMATION BY GUANYLIC ACID
Gellert, M., Lipsett, M. N., & Davies, D. R. (1962) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.48.12.2013 · Cited by 1,643
Long-range correlations in nucleotide sequences
Peng, C.-K., Buldyrev, S. V., Goldberger, A. L., Havlin, S., Sciortino, F., Simons, M., & Stanley, H. E. (1992) · Nature · doi:10.1038/356168a0 · Cited by 1,410
Monovalent cation-induced structure of telomeric DNA: The G-quartet model
Williamson, J. R., Raghuraman, M. K., & Cech, T. R. (1989) · Cell · doi:10.1016/0092-8674(89)90610-7 · Cited by 1,225
Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops
Sundquist, W. I., & Klug, A. (1989) · Nature · doi:10.1038/342825a0 · Cited by 974
Henderson, E., Hardin, C. C., Walk, S. K., Tinoco, I., & Blackburn, E. H. (1987) · Cell · doi:10.1016/0092-8674(87)90577-0 · Cited by 692
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DNA tetraplex formation in the control region of c-myc
Simonsson, T. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.5.1167 · Cited by 598
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C9orf72 nucleotide repeat structures initiate molecular cascades of disease
Haeusler, A. R., Donnelly, C. J., Periz, G., Simko, E. A. J., Shaw, P. G., Kim, M.-S., Maragakis, N. J., Troncoso, J. C., Pandey, A., Sattler, R., et al. (2014) · Nature · doi:10.1038/nature13124 · Cited by 978
Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes
Huppert, J. L. (2008) · Chemical Society Reviews · doi:10.1039/b702491f · Cited by 494
Self-citationBrooks, T. A., & Hurley, L. H. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2733 · Cited by 294
Metadata
- Authors
- Hazel, P., Huppert, J., Balasubramanian, S., & Neidle, S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-11-23
- Volume
- 126
- Issue
- 50
- Pages
- 16405-16415
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1975690779
- Cited by
- 494
- References
- 33
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- closed
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