The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes
Abstract
There are many structures that can be adopted by nucleic acids other than the famous Watson-Crick duplex form. This tutorial review describes the guanine rich G-quadruplex structure, highlighting the chemical interactions governing its formation, and the topological variants that exist. The methods that are used to study G-quadruplex structures are described, with examples of the information that may be derived from these different methods. Next, the proposed biological functions of G-quadruplexes are discussed, highlighting especially their presence in telomeric regions and gene promoters. G-quadruplex structures are the subject of considerable interest for the development of small-molecule ligands, and are also the targets of a wide variety of natural proteins.
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Citations
Cites
Structure and function of telomeres
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Self-citationHELIX FORMATION BY GUANYLIC ACID
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Self-citationSolution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex
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CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo
Moreno-Mateos, M. A., Vejnar, C. E., Beaudoin, J.-D., Fernandez, J. P., Mis, E. K., Khokha, M. K., & Giraldez, A. J. (2015) · Nature Methods · doi:10.1038/nmeth.3543 · Cited by 1,290
C9orf72 nucleotide repeat structures initiate molecular cascades of disease
Haeusler, A. R., Donnelly, C. J., Periz, G., Simko, E. A. J., Shaw, P. G., Kim, M.-S., Maragakis, N. J., Troncoso, J. C., Pandey, A., Sattler, R., et al. (2014) · Nature · doi:10.1038/nature13124 · Cited by 978
5′-UTR G-quadruplex structures acting as translational repressors
Beaudoin, J.-D., & Perreault, J.-P. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq557 · Cited by 255
Crosstalk between G-quadruplex and ROS
Wu, S., Jiang, L., Lei, L., Fu, C., Huang, J., Hu, Y., Dong, Y., Chen, J., & Zeng, Q. (2023) · Cell Death & Disease · doi:10.1038/s41419-023-05562-0 · Cited by 69
“G-quadruplex (G4) is a four-stranded nucleic acid structure formed by guanine-rich DNA and RNA sequences with Hoogsteen hydrogen bonding [11, 12].”
BackgroundThe function of DNA binding protein nucleophosmin in AAV replication
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Metadata
- Authors
- Huppert, J. L.
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2008
- Volume
- 37
- Issue
- 7
- Pages
- 1375
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2010999047
- Cited by
- 494
- References
- 50
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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