The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Boolean Logic Functions of a Synthetic Peptide Network
Open accessAbstract
Living cells can process rapidly and simultaneously multiple extracellular input signals through the complex networks of evolutionary selected biomolecular interactions and chemical transformations. Recent approaches to molecular computation have increasingly sought to mimic or exploit various aspects of biology. A number of studies have adapted nucleic acids and proteins to the design of molecular logic gates and computational systems, while other works have affected computation in living cells via biochemical pathway engineering. Here we report that de novo designed synthetic peptide networks can also mimic some of the basic logic functions of the more complex biological networks. We show that segments of a small network whose graph structure is composed of five nodes and 15 directed edges can express OR, NOR, and NOTIF logic.
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Cites
Hierarchical Organization of Modularity in Metabolic Networks
Ravasz, E., Somera, A. L., Mongru, D. A., Oltvai, Z. N., & Barabási, A.-L. (2002) · Science · doi:10.1126/science.1073374 · Cited by 4,224
Transcriptional Regulatory Networks in Saccharomyces cerevisiae
Lee, T. I., Rinaldi, N. J., Robert, F., Odom, D. T., Bar-Joseph, Z., Gerber, G. K., Hannett, N. M., Harbison, C. T., Thompson, C. M., Simon, I., et al. (2002) · Science · doi:10.1126/science.1075090 · Cited by 2,956
Logical computation using algorithmic self-assembly of DNA triple-crossover molecules
Mao, C., LaBean, T. H., Reif, J. H., & Seeman, N. C. (2000) · Nature · doi:10.1038/35035038 · Cited by 779
Lee, D. H., Granja, J. R., Martinez, J. A., Severin, K., & Ghadiri, M. R. (1996) · Nature · doi:10.1038/382525a0 · Cited by 677
Self-citationAn Age-Induced Switch to a Hyper-Recombinational State
McMurray, M. A., & Gottschling, D. E. (2003) · Science · doi:10.1126/science.1087706 · Cited by 208
Cited by
Dynamic DNA nanotechnology using strand-displacement reactions
Zhang, D. Y., & Seelig, G. (2011) · Nature Chemistry · doi:10.1038/nchem.957 · Cited by 1,785
Prebiotic Systems Chemistry: New Perspectives for the Origins of Life
Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930
Bissette, A. J., & Fletcher, S. P. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201303822 · Cited by 403
A Molecular Full-Adder and Full-Subtractor, an Additional Step toward a Moleculator
Margulies, D., Melman, G., & Shanzer, A. (2006) · Journal of the American Chemical Society · doi:10.1021/ja058564w · Cited by 309
Malakoutikhah, M., Peyralans, J. J.-P., Colomb-Delsuc, M., Fanlo-Virgós, H., Stuart, M. C. A., & Otto, S. (2013) · Journal of the American Chemical Society · doi:10.1021/ja4067805 · Cited by 111
Metadata
- Authors
- Ashkenasy, G., & Ghadiri, M. R.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-08-19
- Volume
- 126
- Issue
- 36
- Pages
- 11140-11141
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2087317632
- Cited by
- 229
- References
- 5
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- green
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