Logical computation using algorithmic self-assembly of DNA triple-crossover molecules
Abstract
Recent work has demonstrated the self-assembly of designed periodic two-dimensional arrays composed of DNA tiles, in which the intermolecular contacts are directed by 'sticky' ends. In a mathematical context, aperiodic mosaics may be formed by the self-assembly of 'Wang' tiles, a process that emulates the operation of a Turing machine. Macroscopic self-assembly has been used to perform computations; there is also a logical equivalence between DNA sticky ends and Wang tile edges. This suggests that the self-assembly of DNA-based tiles could be used to perform DNA-based computation. Algorithmic aperiodic self-assembly requires greater fidelity than periodic self-assembly, because correct tiles must compete with partially correct tiles. Here we report a one-dimensional algorithmic self-assembly of DNA triple-crossover molecules that can be used to execute four steps of a logical (cumulative XOR) operation on a string of binary bits.
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Robust, rigid DNA tiles with programmable "sticky ends" have been made using double-crossover (DX), triple-crossover (TX), and single-stranded tile (SST) motifs and used for algorithmic self-assembly experiments.
“Robust, rigid DNA tiles with programmable “sticky ends” have been made using double-crossover (DX),141 triple-crossover (TX),142 and single-stranded tile (SST)143 motifs and used for a variety of algorithmic self-assembly experiments.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [142]
Cites
Molecular Computation of Solutions to Combinatorial Problems
Adleman, L. M. (1994) · Science · doi:10.1126/science.7973651 · Cited by 4,474 · see citing works
Design and self-assembly of two-dimensional DNA crystals
Winfree, E., Liu, F., Wenzler, L. A., & Seeman, N. C. (1998) · Nature · doi:10.1038/28998 · Cited by 2,857 · see citing works
Self-citationConstruction, Analysis, Ligation, and Self-Assembly of DNA Triple Crossover Complexes
LaBean, T. H., Yan, H., Kopatsch, J., Liu, F., Winfree, E., Reif, J. H., & Seeman, N. C. (2000) · Journal of the American Chemical Society · doi:10.1021/ja993393e · Cited by 704 · see citing works
Self-citationHighly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis
Blackwell, H. E., & Grubbs, R. H. (1998) · Angewandte Chemie International Edition · doi:10.1002/(sici)1521-3773(19981217)37:23 · Cited by 567 · see citing works
Self-citationLiu, Q., Wang, L., Frutos, A. G., Condon, A., Corn, R. M., & Smith, L. M. (2000) · Nature · doi:10.1038/35003155 · Cited by 529 · see citing works
Designed Two-Dimensional DNA Holliday Junction Arrays Visualized by Atomic Force Microscopy
Mao, C., Sun, W., & Seeman, N. C. (1999) · Journal of the American Chemical Society · doi:10.1021/ja9900398 · Cited by 522 · see citing works
Self-citationAlgorithmic Self-Assembly of DNA
Winfree, E. (2006) · International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology (MMB) · doi:10.1109/mmb.2006.251471 · Cited by 488 · see citing works
Molecular Computation by DNA Hairpin Formation
Sakamoto, K., Gouzu, H., Komiya, K., Kiga, D., Yokoyama, S., Yokomori, T., & Hagiya, M. (2000) · Science · doi:10.1126/science.288.5469.1223 · Cited by 388 · see citing works
Molecular computation: RNA solutions to chess problems
Faulhammer, D., Cukras, A. R., Lipton, R. J., & Landweber, L. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1385 · Cited by 338 · see citing works
On the computational power of DNA annealing and ligation
Winfree, E. (1996) · DIMACS series in discrete mathematics and theoretical computer science · doi:10.1090/dimacs/027/09 · Cited by 197 · see citing works
Modifying the Surface Features of Two-Dimensional DNA Crystals
Liu, F., Sha, R., & Seeman, N. C. (1999) · Journal of the American Chemical Society · doi:10.1021/ja982824a · Cited by 136 · see citing works
Self-citationUsing lateral capillary forces to compute by self-assembly
Rothemund, P. W. K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.3.984 · Cited by 134 · see citing works
Proceedings of the symposium on mathematical theory of Automata
Leondes, C. T. (1964) · Proceedings of the IEEE · doi:10.1109/proc.1964.3109 · Cited by 115 · see citing works
Lipton, R., & Baum, E. B. (1996) · DIMACS series in discrete mathematics and theoretical computer science · doi:10.1090/dimacs/027 · Cited by 103 · see citing works
Local parallel biomolecular computation
Reif, J. H. (1999) · DIMACS series in discrete mathematics and theoretical computer science · doi:10.1090/dimacs/048/17 · Cited by 75 · see citing works
Self-citationUnexpected substrate specificity of T4 DNA ligase revealed byin vitroselection
Harada, K., & Orgel, L. E. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.10.2287 · Cited by 53 · see citing works
Pirrung, M. C., Connors, R., Odenbaugh, A. L., Montague-Smith, M. P., Walcott, N. G., & Tollett, J. (2000) · Journal of the American Chemical Society · doi:10.1021/ja992392j · Cited by 44 · see citing works
DNA based computers : proceedings of a DIMACS workshop, April 4, 1995, Princeton University
Lipton, R. J., Baum, E. B., & Dimacs (1996) · American Mathematical Society eBooks · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Seeman, N. C. (2003) · Nature · doi:10.1038/nature01406 · Cited by 2,792 · see citing works
Self-citationSeeman, N. C., & Sleiman, H. F. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.68 · Cited by 1,875 · see citing works
Self-citationDNA-Templated Self-Assembly of Protein Arrays and Highly Conductive Nanowires
Yan, H., Park, S. H., Finkelstein, G., Reif, J. H., & LaBean, T. H. (2003) · Science · doi:10.1126/science.1089389 · Cited by 1,765 · see citing works
Self-citationSeeman, N. C. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060308-102244 · Cited by 992 · see citing works
Self-citationAlgorithmic Self-Assembly of DNA Sierpinski Triangles
Rothemund, P. W. K., Papadakis, N., & Winfree, E. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020424 · Cited by 860 · see citing works
An autonomous molecular computer for logical control of gene expression
Benenson, Y., Gil, B., Ben-Dor, U., Adar, R., & Shapiro, E. Y. (2004) · Nature · doi:10.1038/nature02551 · Cited by 816 · see citing works
Programmable and autonomous computing machine made of biomolecules
Benenson, Y., Paz-Elizur, T., Adar, R., Keinan, E., Livneh, Z., & Shapiro, E. Y. (2001) · Nature · doi:10.1038/35106533 · Cited by 645 · see citing works
A deoxyribozyme-based molecular automaton
Stojanović, M. N., & Stefanović, D. (2003) · Nature Biotechnology · doi:10.1038/nbt862 · Cited by 624 · see citing works
de Silva, A. P., & McClenaghan, N. D. (2004) · Chemistry - A European Journal · doi:10.1002/chem.200305054 · Cited by 612 · see citing works
Solution of a 20-Variable 3-SAT Problem on a DNA Computer
Braich, R. S., Chelyapov, N. V., Johnson, C., Rothemund, P. W. K., & Adleman, L. M. (2002) · Science · doi:10.1126/science.1069528 · Cited by 567 · see citing works
Rational Design of DNA Nanoarchitectures
Feldkamp, U., & Niemeyer, C. M. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200502358 · Cited by 541 · see citing works
Li, X., & Liu, D. R. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200400656 · Cited by 538 · see citing works
Near-Complete Suppression of Quantum Dot Blinking in Ambient Conditions
Hohng, S., & Ha, T. (2004) · Journal of the American Chemical Society · doi:10.1021/ja039686w · Cited by 515 · see citing works
Terahertz Frequency Sensing and Imaging: A Time of Reckoning Future Applications?
WOOLARD, D. L., Brown, R., Pepper, M., & Kemp, M. C. (2005) · Proceedings of the IEEE · doi:10.1109/jproc.2005.853539 · Cited by 447 · see citing works
An Overview of Structural DNA Nanotechnology
Seeman, N. C. (2007) · Molecular Biotechnology · doi:10.1007/s12033-007-0059-4 · Cited by 450 · see citing works
Self-citationDNA computing circuits using libraries of DNAzyme subunits
Elbaz, J., Lioubashevski, O., Wang, F., Remacle, F., Levine, R. D., & Willner, I. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2010.88 · Cited by 449 · see citing works
Smart Drug Delivery Nanocarriers with Self‐Assembled DNA Nanostructures
Li, J., Fan, C., Pei, H., Shi, J., & Huang, Q. (2013) · Advanced Materials · doi:10.1002/adma.201300875 · Cited by 440 · see citing works
Artificial Chemistries—A Review
Dittrich, P., Ziegler, J., & Banzhaf, W. (2001) · Artificial Life · doi:10.1162/106454601753238636 · Cited by 422 · see citing works
Emulating biology: Building nanostructures from the bottom up
Seeman, N. C., & Belcher, A. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221458298 · Cited by 419 · see citing works
Self-citationHamad‐Schifferli, K., Schwartz, J. J., Santos, A. T., Zhang, S., & Jacobson, J. M. (2002) · Nature · doi:10.1038/415152a · Cited by 398 · see citing works
DNA Tile Based Self‐Assembly: Building Complex Nanoarchitectures
Lin, C., Liu, Y., Rinker, S. D., & Yan, H. (2006) · ChemPhysChem · doi:10.1002/cphc.200600260 · Cited by 385 · see citing works
Biomolecular computing systems: principles, progress and potential
Benenson, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3197 · Cited by 374 · see citing works
Sundaramurthy, A., Schuck, P. J., Conley, N. R., Fromm, D. P., Kino, G. S., & Moerner, W. E. (2006) · Nano Letters · doi:10.1021/nl052322c · Cited by 368 · see citing works
Using DNA to program the self-assembly of colloidal nanoparticles and microparticles
Rogers, W. B., Shih, W. M., & Manoharan, V. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.8 · Cited by 362 · see citing works
Li, J., Green, A. A., Yan, H., & Fan, C. (2017) · Nature Chemistry · doi:10.1038/nchem.2852 · Cited by 353 · see citing works
DNA nanotubes self-assembled from triple-crossover tiles as templates for conductive nanowires
Liu, D., Park, S. H., Reif, J. H., & LaBean, T. H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305860101 · Cited by 336 · see citing works
Self-citationUsing DNA to Power Nanostructures
Yurke, B., & Mills, A. P. (2003) · Genetic Programming and Evolvable Machines · doi:10.1023/a:1023928811651 · Cited by 311 · see citing works
Directed nucleation assembly of DNA tile complexes for barcode-patterned lattices
Yan, H., LaBean, T. H., Feng, L., & Reif, J. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032954100 · Cited by 312 · see citing works
Self-citationDiverse and robust molecular algorithms using reprogrammable DNA self-assembly
Woods, D., Doty, D., Myhrvold, C., Hui, J., Zhou, F., Yin, P., & Winfree, E. (2019) · Nature · doi:10.1038/s41586-019-1014-9 · Cited by 295 · see citing works
DNA‐Encoded Self‐Assembly of Gold Nanoparticles into One‐Dimensional Arrays
Deng, Z., Tian, Y., Lee, S., Ribbe, A. E., & Mao, C. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200463096 · Cited by 295 · see citing works
Self-citationGehani, A., LaBean, T. H., & Reif, J. H. (2003) · Lecture notes in computer science · doi:10.1007/978-3-540-24635-0_12 · Cited by 290 · see citing works
Self-citationFinite‐Size, Fully Addressable DNA Tile Lattices Formed by Hierarchical Assembly Procedures
Park, S. H., Pistol, C., Ahn, S. J., Reif, J. H., Lebeck, A. R., Dwyer, C. L., & LaBean, T. H. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200503797 · Cited by 283 · see citing works
Self-citationEnergy Dissipation in Multichromophoric Single Dendrimers
Schryver, F. C. D., Vosch, T., Cotlet, M., der Auweraer, M. V., Müllen, K., & Hofkens, J. (2004) · Accounts of Chemical Research · doi:10.1021/ar040126r · Cited by 273 · see citing works
An Autonomous DNA Nanomotor Powered by a DNA Enzyme
Chen, Y., Wang, M., & Mao, C. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200453779 · Cited by 273 · see citing works
Self-citationBalzani, V., Credi, A., & Venturi, M. (2002) · ChemPhysChem · doi:10.1002/cphc.200390007 · Cited by 268 · see citing works
An information-bearing seed for nucleating algorithmic self-assembly
Barish, R. D., Schulman, R., Rothemund, P. W. K., & Winfree, E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808736106 · Cited by 267 · see citing works
DNA-Templated Fabrication of 1D Parallel and 2D Crossed Metallic Nanowire Arrays
Deng, Z., & Mao, C. (2003) · Nano Letters · doi:10.1021/nl034720q · Cited by 260 · see citing works
Self-citationTransfer of molecular recognition information from DNA nanostructures to gold nanoparticles
Edwardson, T. G. W., Lau, K. L., Bousmail, D., Serpell, C. J., & Sleiman, H. F. (2016) · Nature Chemistry · doi:10.1038/nchem.2420 · Cited by 258 · see citing works
DNA molecule provides a computing machine with both data and fuel
Benenson, Y., Adar, R., Paz-Elizur, T., Livneh, Z., & Shapiro, E. Y. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0535624100 · Cited by 255 · see citing works
DNA-programmed assembly of nanostructures
Gothelf, K. V., & LaBean, T. H. (2005) · Organic & Biomolecular Chemistry · doi:10.1039/b510551j · Cited by 253 · see citing works
Self-citationComplexity of Self‐Assembled Shapes
Soloveichik, D., & Winfree, E. (2007) · SIAM Journal on Computing · doi:10.1137/s0097539704446712 · Cited by 252 · see citing works
Golgins in the structure and dynamics of the Golgi apparatus
Barr, F. A., & Short, B. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00054-1 · Cited by 252 · see citing works
Rab1 Interaction with a GM130 Effector Complex Regulates COPII Vesicle cis‐Golgi Tethering
Moyer, B. D., Allan, B. B., & Balch, W. E. (2001) · Traffic · doi:10.1034/j.1600-0854.2001.1o007.x · Cited by 251 · see citing works
Probing Spatial Organization of DNA Strands Using Enzyme-Free Hairpin Assembly Circuits
Li, B., Jiang, Y. S., Chen, X., & Ellington, A. D. (2012) · Journal of the American Chemical Society · doi:10.1021/ja300984b · Cited by 251 · see citing works
Self-assembled nanostructures based on DNA: towards the development of nanobiotechnology
Niemeyer, C. M. (2000) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(00)00140-x · Cited by 244 · see citing works
Optimized DNA “Nanosuitcases” for Encapsulation and Conditional Release of siRNA
Bujold, K. E., Hsu, J. C. C., & Sleiman, H. F. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b08369 · Cited by 242 · see citing works
The many facets of natural computing
Lila Kari, A., & Rozenberg, G. (2008) · Communications of the ACM · doi:10.1145/1400181.1400200 · Cited by 239 · see citing works
Fragmentation of the Golgi apparatus in neurodegenerative diseases and cell death
Gonatas, N. K., Stieber, A., & Gonatas, J. O. (2006) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2006.01.019 · Cited by 236 · see citing works
Emerging Approaches to DNA Data Storage: Challenges and Prospects
Doricchi, A., Platnich, C. M., Gimpel, A., Horn, F., Earle, M., Lanzavecchia, G., Cortajarena, A. L., Liz-Marzán, L. M., Liu, N., Heckel, R., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c06748 · Cited by 235 · see citing works
Running time and program size for self-assembled squares
Adleman, L. M., Cheng, Q., Goel, A., & Huang, M.-D. A. (2001) · ACM Symposium on Theory of Computing (STOC) · doi:10.1145/380752.380881 · Cited by 234 · see citing works
Boolean Logic Functions of a Synthetic Peptide Network
Ashkenasy, G., & Ghadiri, M. R. (2004) · Journal of the American Chemical Society · doi:10.1021/ja046745c · Cited by 229 · see citing works
Backbone-induced semiconducting behavior in short DNA wires
Cuniberti, G., Craco, L., Porath, D., & Dekker, C. (2002) · Physical review. B, Condensed matter · doi:10.1103/physrevb.65.241314 · Cited by 220 · see citing works
Integrating DNA strand-displacement circuitry with DNA tile self-assembly
Zhang, D. Y., Hariadi, R. F., Choi, H. M. T., & Winfree, E. (2013) · Nature Communications · doi:10.1038/ncomms2965 · Cited by 219 · see citing works
Three-Helix Bundle DNA Tiles Self-Assemble into 2D Lattice or 1D Templates for Silver Nanowires
Park, S. H., Barish, R. D., Li, H., Reif, J. H., Finkelstein, G., Yan, H., & LaBean, T. H. (2005) · Nano Letters · doi:10.1021/nl050108i · Cited by 213 · see citing works
Self-citationProofreading Tile Sets: Error Correction for Algorithmic Self-Assembly
Winfree, E., & Bekbolatov, R. (2004) · Lecture notes in computer science · doi:10.1007/978-3-540-24628-2_13 · Cited by 209 · see citing works
Robust and emergent Physarum logical-computing
Tsuda, S., Aono, M., & Gunji, Y. (2003) · Biosystems · doi:10.1016/j.biosystems.2003.08.001 · Cited by 192 · see citing works
Bottom-up Assembly of RNA Arrays and Superstructures as Potential Parts in Nanotechnology
Shu, D., Moll, W., Deng, Z., Mao, C., & Guo, P. (2004) · Nano Letters · doi:10.1021/nl0494497 · Cited by 184 · see citing works
Self-citationDNA computing: applications and challenges
Ezziane, Z. (2005) · Nanotechnology · doi:10.1088/0957-4484/17/2/r01 · Cited by 183 · see citing works
At the Crossroads of Chemistry, Biology, and Materials
Seeman, N. C. (2003) · Chemistry & Biology · doi:10.1016/j.chembiol.2003.12.002 · Cited by 182 · see citing works
Self-citationNanofabrication by DNA self-assembly
Li, H., Carter, J. D., & LaBean, T. H. (2009) · Materials Today · doi:10.1016/s1369-7021(09)70157-9 · Cited by 181 · see citing works
Self-citationA New Algorithm for RNA Secondary Structure Design
Andronescu, M., Fejes, A. P., Hutter, F., Hoos, H. H., & Condon, A. (2003) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.12.041 · Cited by 179 · see citing works
Smart Nanomaterials Responsive to Multiple Chemical Stimuli with Controllable Cooperativity
Liu, J., & Lu, Y. (2006) · Advanced Materials · doi:10.1002/adma.200600525 · Cited by 176 · see citing works
Gissot, A., Camplo, M., Grinstaff, M. W., & Barthélémy, P. (2008) · Organic & Biomolecular Chemistry · doi:10.1039/b719280k · Cited by 171 · see citing works
Nucleic acid nanostructures: bottom-up control of geometry on the nanoscale
Seeman, N. C., & Lukeman, P. S. (2004) · Reports on Progress in Physics · doi:10.1088/0034-4885/68/1/r05 · Cited by 170 · see citing works
Self-citationRNA Nanotechnology: Engineering, Assembly and Applications in Detection, Gene Delivery and Therapy
Guo, P. (2005) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2005.446 · Cited by 164 · see citing works
DNA-Based Biosensors for the Biochemical Analysis: A Review
Hua, Y., Ma, J., Li, D., & Wang, R. (2022) · Biosensors · doi:10.3390/bios12030183 · Cited by 159 · see citing works
Biocomputing based on particle disassembly
Nikitin, M. P., Shipunova, V. O., Deyev, S. M., & Nikitin, P. I. (2014) · Nature Nanotechnology · doi:10.1038/nnano.2014.156 · Cited by 157 · see citing works
Molecular basis for Golgi maintenance and biogenesis
Altan‐Bonnet, N., Sougrat, R., & Lippincott‐Schwartz, J. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.06.011 · Cited by 156 · see citing works
Intelligent Medical Diagnostics via Molecular Logic
Konry, T., & Walt, D. R. (2009) · Journal of the American Chemical Society · doi:10.1021/ja905125b · Cited by 154 · see citing works
The unique architecture of Bunyamwera virus factories around the Golgi complex
Fontana, J., López-Montero, N., Elliott, R. M., Fernández, J., & Risco, C. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01184.x · Cited by 153 · see citing works
Thirteen Years of Single-Molecule Spectroscopy in Physical Chemistry and Biophysics
Moerner, W. E. (2001) · Springer series in chemical physics · doi:10.1007/978-3-642-56544-1_2 · Cited by 154 · see citing works
Biocomputers: from test tubes to live cells
Benenson, Y. (2009) · Molecular BioSystems · doi:10.1039/b902484k · Cited by 151 · see citing works
Parallel computation with molecular-motor-propelled agents in nanofabricated networks
Nicolau, D. V., Lard, M., Korten, T., van Delft, F. C. M. J. M., Persson, M., Bengtsson, E., Månsson, A., Diez, S., Linke, H., & Nicolau, D. V. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510825113 · Cited by 152 · see citing works
Rationaler Entwurf von DNA‐Nanoarchitekturen
Feldkamp, U., & Niemeyer, C. M. (2006) · Angewandte Chemie · doi:10.1002/ange.200502358 · Cited by 151 · see citing works
A double-stranded DNA rotaxane
Ackermann, D., Schmidt, T. L., Hannam, J. S., Purohit, C. S., Heckel, A., & Famulok, M. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2010.65 · Cited by 149 · see citing works
Graczyk, A., Pawłowska, R., Jędrzejczyk, D., & Chworoś, A. (2020) · Molecules · doi:10.3390/molecules25010204 · Cited by 148 · see citing works
Designed DNA molecules: principles and applications of molecular nanotechnology
Condon, A. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1892 · Cited by 146 · see citing works
The Flexibility of DNA Double Crossover Molecules
Sa-Ardyen, P., Vologodskii, A. V., & Seeman, N. C. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)75110-8 · Cited by 146 · see citing works
Self-citationDNA biomolecular-electronic encoder and decoder devices constructed by multiplex biosensors
Kang, D., White, R. J., Xia, F., Zuo, X., Vallée‐Bélisle, A., & Plaxco, K. W. (2012) · NPG Asia Materials · doi:10.1038/am.2012.1 · Cited by 145 · see citing works
Combinatorial optimization problems in self-assembly
Adleman, L., Cheng, Q., Goel, A., Huang, M.-D. A., Kempe, D., de Espanés, P. M., & Rothemund, P. W. K. (2002) · ACM Symposium on Theory of Computing (STOC) · doi:10.1145/509907.509913 · Cited by 144 · see citing works
Zhu, N., Chang, Z., He, P., & Fang, Y. (2005) · Electrochimica Acta · doi:10.1016/j.electacta.2005.10.038 · Cited by 143 · see citing works
Nanoscale Conjugated-Polymer Light-Emitting Diodes
Boroumand, F. A., Fry, P. W., & Lidzey, D. G. (2004) · Nano Letters · doi:10.1021/nl048382k · Cited by 142 · see citing works
DNA Self-assembly for Nanomedicine
Chhabra, R., Sharma, J., Liu, Y., Rinker, S. D., & Yan, H. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.03.005 · Cited by 141 · see citing works
Dynamic patterning programmed by DNA tiles captured on a DNA origami substrate
Gu, H., Chao, J., Xiao, S., & Seeman, N. C. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.5 · Cited by 141 · see citing works
Self-citationColorimetric Logic Gates Based on Supramolecular DNAzyme Structures
Bi, S., Yan, Y., Hao, S., & Zhang, S. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201000840 · Cited by 139 · see citing works
Schaffert, D., Okholm, A. H., Sørensen, R. S., Nielsen, J. S., Tørring, T., Rosen, C. B., Kodal, A. L. B., Mortensen, M. R., Gothelf, K. V., & Kjems, J. (2016) · Small · doi:10.1002/smll.201503934 · Cited by 139 · see citing works
Staged self-assembly: nanomanufacture of arbitrary shapes with O(1) glues
Demaine, E. D., Demaine, M. L., Fekete, S. P., Ishaque, M., Rafalin, E., Schweller, R., & Souvaine, D. L. (2008) · Natural Computing · doi:10.1007/s11047-008-9073-0 · Cited by 138 · see citing works
Weston, K. D., Dyck, M., Tinnefeld, P., Müller, C., Herten, D., & Sauer, M. (2002) · Analytical Chemistry · doi:10.1021/ac025730z · Cited by 135 · see citing works
Structural DNA Nanotechnology: An Overview
Seeman, N. C. (2005) · Humana Press eBooks · doi:10.1385/1-59259-901-x:143 · Cited by 140 · see citing works
Self-citationWei, J., & Seemann, J. (2010) · Traffic · doi:10.1111/j.1600-0854.2010.01114.x · Cited by 134 · see citing works
Li, X., & Liu, D. R. (2004) · Angewandte Chemie · doi:10.1002/ange.200400656 · Cited by 134 · see citing works
Robust self-replication of combinatorial information via crystal growth and scission
Schulman, R., Yurke, B., & Winfree, E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117813109 · Cited by 132 · see citing works
DNA as a universal chemical substrate for computing and data storage
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Moore, M. J., Enomoto, A., Nakano, T., Egashira, R., Suda, T., Kayasuga, A., Kojima, H., Sakakibara, H., & Oiwa, K. (2006) · IEEE International Conference on Pervasive Computing and Communications Workshops (PerCom Workshops) · doi:10.1109/percomw.2006.4 · Cited by 131 · see citing works
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Patwa, A. N., Gissot, A., Berque‐Bestel, I., & Barthélémy, P. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15038c · Cited by 120 · see citing works
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Mavroidis, C., Dubey, A., & Yarmush, M. L. (2004) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.6.040803.140143 · Cited by 118 · see citing works
- Authors
- Mao, C., LaBean, T. H., Reif, J. H., & Seeman, N. C.
- Affiliations
- New York University (US)
- Duke University (US)
- Corresponding author
- Seeman, Nadrian C.
- Venue
- Nature
- Published
- 2000-09-28
- Volume
- 407
- Issue
- 6803
- Pages
- 493-496
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1628582474
- Cited by
- 779
- References
- 18
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 10 · 2023: 17 · 2022: 14 · 2021: 20 · 2020: 14 · 2019: 13 · 2018: 16 · 2017: 16 · 2016: 27 · 2015: 46 · 2014: 37 · 2013: 33 · 2012: 41
- FWCI
- 11.92
- Type
- journal article
- Language
- en
- Update notices
- erratum (2000-12-07)
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Science Foundation
- National Institutes of Health
- Defense Advanced Research Projects Agency
- Army Research Office
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Biological Computing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Computer Science › Computational Theory and Mathematics › Computability, Logic, AI Algorithms
- Keywords
- DNA self-assembly, DNA computing, algorithmic self-assembly, Wang tiles, sticky ends, binary logic, one-dimensional self-assembly
- MeSH terms
- Algorithms, DNA, Nucleic Acid Conformation, Computational Biology
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