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Propeller-Type Parallel-Stranded G-Quadruplexes in the Human c-myc Promoter
Open accessAbstract
The nuclease-hypersensitivity element III1 in the c-myc promoter is a good anticancer target since it largely controls transcriptional activation of the important c-myc oncogene. Recently, the guanine-rich strand of this element has been shown to form an equilibrium between G-quadruplex structures built from two different sets of G-stretches; two models of intramolecular fold-back antiparallel-stranded G-quadruplexes, called "basket" and "chair" forms, were proposed. Here, we show by NMR that two sequences containing these two sets of G-stretches form intramolecular propeller-type parallel-stranded G-quadruplexes in K(+)-containing solution. The two structures involve a core of three stacked G-tetrads formed by four parallel G-stretches with all anti guanines and three double-chain-reversal loops bridging three G-tetrad layers. The central loop contains two or six residues, while the two other loops contain only one residue.
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Citations
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Metadata
- Authors
- Phan, A. T., Modi, Y. S., & Patel, D. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-06-22
- Volume
- 126
- Issue
- 28
- Pages
- 8710-8716
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1980513386
- Cited by
- 501
- References
- 0
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- green
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