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Carbon Nanotubes as Intracellular Protein Transporters: Generality and Biological Functionality
Open accessAbstract
Various proteins adsorb spontaneously on the sidewalls of acid-oxidized single-walled carbon nanotubes. This simple nonspecific binding scheme can be used to afford noncovalent protein-nanotube conjugates. The proteins are found to be readily transported inside various mammalian cells with nanotubes acting as the transporter via the endocytosis pathway. Once released from the endosomes, the internalized protein-nanotube conjugates can enter into the cytoplasm of cells and perform biological functions, evidenced by apoptosis induction by transported cytochrome c. Carbon nanotubes represent a new class of molecular transporters potentially useful for future in vitro and in vivo protein delivery applications.
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Cited by
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Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
The biocompatibility of carbon nanotubes
Smart, S. K., Cassady, A. I., Lu, G. Q., & Martin, D. J. (2006) · Carbon · doi:10.1016/j.carbon.2005.10.011 · Cited by 1,011
Tailoring nanocarriers for intracellular protein delivery
Gu, Z., Biswas, A., Zhao, M., & Tang, Y. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00227e · Cited by 543
Receptor-Mediated Endocytosis of Nanoparticles of Various Shapes
Vácha, R., Martinez-Veracoechea, F. J., & Frenkel, D. (2011) · Nano Letters · doi:10.1021/nl2030213 · Cited by 494
Metadata
- Authors
- Kam, N. W. S., & Dai, H.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-03-31
- Volume
- 127
- Issue
- 16
- Pages
- 6021-6026
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1980695842
- Cited by
- 1,047
- References
- 0
- FWCI
- 42.40
- Type
- journal article
- Language
- en
- Open access
- green
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