The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Direct Molecular Detection of Nucleic Acids by Fluorescence Signal Amplification
Open accessAbstract
An integrated PCR-free DNA sensor, which combines a sequence-specific receptor, an optical polymeric transducer, and an intrinsic fluorescence amplification mechanism, is reported. This sensor is based on the different conformations adopted by a cationic polythiophene when electrostatically bound to ss-DNA or ds-DNA, and on the efficient and fast energy transfer between the resulting fluorescent polythiophene/ds-DNA complex and neighboring fluorophores attached to ss-DNA probes. This molecular system allows the detection of only five molecules in 3 mL of an aqueous solution, or 3 zM, in 5 min. Moreover, this work demonstrates, for the first time, the direct detection of single nucleotide polymorphisms (SNPs) from clinical samples in only a few minutes, without the need for nucleic acid amplification.
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Cites
Saiki, R. K., Scharf, S., Faloona, F., Mullis, K. B., Horn, G. T., Erlich, H. A., & Arnheim, N. (1985) · Science · doi:10.1126/science.2999980 · Cited by 8,956
Drummond, T. G., Hill, M. G., & Barton, J. K. (2003) · Nature Biotechnology · doi:10.1038/nbt873 · Cited by 2,214
Phaneuf, D., Lambert, M., Laframboise, R., Mitchell, G., Lettre, F., & Tanguay, R. M. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115979 · Cited by 84
Self-citation
Cited by
Conducting polymers in biomedical engineering
Guimard, N. K., Gomez, N., & Schmidt, C. E. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.05.012 · Cited by 1,599
Electronic Aptamer‐Based Sensors
Willner, I., & Zayats, M. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200604524 · Cited by 818
Wang, F., Lu, C.-H., & Willner, I. (2014) · Chemical Reviews · doi:10.1021/cr400354z · Cited by 649
Feng, X., Liu, L., Wang, S., & Zhu, D. (2010) · Chemical Society Reviews · doi:10.1039/b909065g · Cited by 621
Duan, X., Liu, L., Feng, F., & Wang, S. (2010) · Accounts of Chemical Research · doi:10.1021/ar9001813 · Cited by 273
Metadata
- Authors
- Ho, H. A., Doré, Boissinot, M., Bergeron, M. G., Tanguay, R. M., Boudreau, D., & Leclerc, M.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-08-18
- Volume
- 127
- Issue
- 36
- Pages
- 12673-12676
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1972078733
- Cited by
- 264
- References
- 3
- FWCI
- 9.33
- Type
- journal article
- Language
- en
- Open access
- green
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
