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Charged Polypeptide Vesicles with Controllable Diameter
Abstract
We report the preparation and characterization of charged, amphiphilic block copolypeptides that form stable vesicles and micelles in aqueous solution. Specifically, we prepared and studied the aqueous self-assembly of a series of poly(L-lysine)-b-poly(L-leucine) block copolypeptides, KxLy, where x ranged from 20 to 80 and y ranged from 10 to 30 residues, as well as the poly(L-glutamatic acid)-b-poly(L-leucine) block copolypeptide, E60L20. Furthermore, the vesicular assemblies show dynamic properties, indicating a high degree of membrane fluidity. This characteristic provides stimuli-responsive properties to the vesicles and allows fine adjustment of vesicle size using liposome-based extrusion techniques. Vesicle extrusion also provides a straightforward means to trap solutes, making the vesicles promising biomimetic encapsulants.
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Cited by
Blanazs, A., Armes, S. P., & Ryan, A. J. (2009) · Macromolecular Rapid Communications · doi:10.1002/marc.200800713 · Cited by 1,500
Self-assembling materials for therapeutic delivery
Branco, M. C., & Schneider, J. P. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2008.09.018 · Cited by 462
Deng, C., Wu, J., Cheng, R., Meng, F., Klok, H.-A., & Zhong, Z. (2014) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2013.10.008 · Cited by 371
Polymeric nanostructured materials for biomedical applications
Tang, Z., He, C., Tian, H., Ding, J., Hsiao, B. S., Chu, B., & Chen, X. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2016.05.005 · Cited by 363
A review of polypeptide-based polymersomes
Zhao, L., Li, N., Wang, K., Shi, C., Zhang, L., & Luan, Y. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.10.063 · Cited by 149
Metadata
- Authors
- Holowka, E. P., Pochan, D. J., & Deming, T. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-08-16
- Volume
- 127
- Issue
- 35
- Pages
- 12423-12428
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1967366094
- Cited by
- 363
- References
- 0
- FWCI
- 11.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Holowka, E. P., Pochan, D. J., & Deming, T. J. (2005). Charged Polypeptide Vesicles with Controllable Diameter. Journal of the American Chemical Society. https://doi.org/10.1021/ja053557t
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