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MRI Thermometry Based on PARACEST Agents

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Zhang, Shanrong, Malloy, Craig R., Sherry, A. Dean·2005·Journal of the American Chemical Society
DOI 10.1021/ja053799t
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Abstract

A novel magnetic resonance imaging (MRI) thermometry technique is demonstrated in vitro based upon the use of a PARACEST (PARAmagnetic Chemical Exchange Saturation Transfer) agent. This new method takes advantage of the high concentration of bulk water (the readout signal for imaging) and the hyperfine frequency shift properties of PARACEST agents. For two prototypes, Dy(1)3+ and Eu(2)-, the chemical shifts (delta, in ppm) of the Ln3+-bound water molecules are linearly dependent on temperature (T, in degrees C) over the range of 20-50 degrees C (delta = 6.9 x T - 944.7 and delta = -0.4 x T + 64.6, respectively). This offers the exciting possibility of improving the temperature dependencies approximately 690- and approximately 40-fold over the most widely used water PRF thermometry (Proton Resonance Frequency: -0.01 ppm/ degrees C).

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Metadata

Authors
Zhang, S., Malloy, C. R., & Sherry, A. D.
Venue
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Published
2005-11-30
Volume
127
Issue
50
Pages
17572-17573
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
DOI
10.1021/ja053799t
OpenAlex
W1972891920
Cited by
173
References
0
FWCI
4.23
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: MRI Thermometry Based on PARACEST Agents. https://app.cochat.ai/papers/10.1021/ja053799t
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Zhang, S., Malloy, C. R., & Sherry, A. D. (2005). MRI Thermometry Based on PARACEST Agents. Journal of the American Chemical Society. https://doi.org/10.1021/ja053799t

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