The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
A General Organocatalyst for Direct α-Functionalization of Aldehydes: Stereoselective C−C, C−N, C−F, C−Br, and C−S Bond-Forming Reactions. Scope and Mechanistic Insights
Abstract
The development of a general organocatalyst for the alpha-functionalization of aldehydes, via an enamine intermediate, is presented. Based on optically active alpha,alpha-diarylprolinol silyl ethers, the scope and applications of this catalyst for the stereogenic formation of C-C, C-N, C-F, C-Br, and C-S bonds are outlined. The reactions all proceed in good to high yields and with excellent enantioselectivities. Furthermore, we will present mechanistic insight into the reaction course applying nonlinear effect studies, kinetic resolution, and computational investigations leading to an understanding of the properties of the alpha,alpha-diarylprolinol silyl ether catalysts.
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Cites
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Self-citationAsymmetric Aminocatalysis—Gold Rush in Organic Chemistry
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Self-citationAsymmetric Organocatalysis: From Infancy to Adolescence
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Metadata
- Authors
- Franzén, J., Marigo, M., Fielenbach, D., Wabnitz, T. C., Kjærsgaard, A., & Jørgensen, K. A.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-12-01
- Volume
- 127
- Issue
- 51
- Pages
- 18296-18304
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2013092331
- Cited by
- 640
- References
- 20
- FWCI
- 24.41
- Type
- journal article
- Language
- en
- Open access
- closed
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