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pH-Sensitive Vesicles Based on a Biocompatible Zwitterionic Diblock Copolymer
Abstract
Highly biocompatible pH-sensitive diblock copolymer vesicles were prepared from the self-assembly of a biocompatible zwitterionic copolymer, poly[2-(methacryloyloxy)ethyl phosphorylcholine-block-2-(diisopropylamino)ethyl methacrylate], PMPC-b-PDPA. Vesicle formation occurred spontaneously by adjusting the solution pH from pH 2 to above 6, with the hydrophobic PDPA chains forming the vesicle walls. Transmission electron microscopy (TEM), dynamic laser light scattering (DLS), and UV-visible absorption spectrophotometry were used to characterize these vesicles. Gold nanoparticle-decorated vesicles were also obtained by treating the vesicles with HAuCl4, followed by NaBH4.
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Citations
Cited by
Blanazs, A., Armes, S. P., & Ryan, A. J. (2009) · Macromolecular Rapid Communications · doi:10.1002/marc.200800713 · Cited by 1,500
Self-citationStimuli-Responsive Polymersomes for Programmed Drug Delivery
Meng, F., Zhong, Z., & Feijen, J. (2009) · Biomacromolecules · doi:10.1021/bm801127d · Cited by 1,122
Ge, Z., & Liu, S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60048c · Cited by 914
Multi-Stimuli Sensitive Amphiphilic Block Copolymer Assemblies
Klaikherd, A., Nagamani, C., & Thayumanavan, S. (2009) · Journal of the American Chemical Society · doi:10.1021/ja809475a · Cited by 594
Chen, W., Meng, F., Cheng, R., & Zhong, Z. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.09.023 · Cited by 458
Metadata
- Authors
- Du, J., Tang, Y., Lewis, A. L., & Armes, S. P.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-12-01
- Volume
- 127
- Issue
- 51
- Pages
- 17982-17983
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1999393639
- Cited by
- 603
- References
- 0
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- closed
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