Multi-Stimuli Sensitive Amphiphilic Block Copolymer Assemblies
Open accessAbstract
Stimuli-responsive polymers are arguably the most widely considered systems for a variety of applications in biomedical arena. We report here a novel triple stimuli sensitive block copolymer assembly that responds to changes in temperature, pH and redox potential. Our block copolymer design constitutes an acid-sensitive THP-protected HEMA as the hydrophobic part and a temperature-sensitive PNIPAM as the hydrophilic part with an intervening disulfide bond. The micellar properties and the release kinetics of the encapsulated guest molecule in response to one stimulus as well as combinations of stimuli have been evaluated. Responsiveness to combination of stimuli not only allows for fine-tuning the guest molecule release kinetics, but also provides the possibility of achieving location-specific delivery.
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The temperature-sensitive hydrophilic part of nanomicelles is turned to hydrophobic above the low critical solution temperature that transfers the polymer to insoluble in water state which, in turn, leads to the assembly.
“the temperature-sensitive hydrophilic part of nanomicelles is turned to hydrophobic above the low critical solution temperature that transfers the polymer to insoluble in water state which, in turn, leads to the assembly.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [217]
The Summary says that above the LCST, the hydrophilic block becomes hydrophobic and the polymer becomes insoluble in water, but this results in “no assembly,” not assembly. The Results and Discussion section on thermosensitive behavior likewise reports precipitation on heating. (LLM, conf=0.95)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe design of multi stimuli-responsive nanomicelles sensitive to redox potential, pH, and temperature was reported recently.
“For example, the design of multi stimuli-responsive nanomicelles sensitive to redox potential, pH, and temperature was reported recently [217].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [217]
The hydrophobic part of the structure tetrahydropyran-protected 2-hydroxyethyl methacrylate aimed to respond acidity change, while the hydrophilic part provided by pNIPAM is temperature sensitive and with redox-potential sensitive disulfide bond between them.
“The hydrophobic part of the structure tetrahydropyran-protected 2-hydroxyethyl methacrylate aimed to respond acidity change, while the hydrophilic part provided by pNIPAM is temperature sensitive and with redox-potential sensitive disulfide bond between them.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [217]
The pH decrease converts acid-sensitive hydrophobic part to hydrophilic and thereby inhibits the assembly.
“The pH decrease, on the other hand, converts acid-sensitive hydrophobic part to hydrophilic and thereby inhibits the assembly.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [217]
Reducing disulfide bonds in such an environment results in the decomposition of nanomicelles.
“Finally, reducing disulfide bonds in such an environment results in the decomposition of nanomicelles [217].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [217]
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“For example, the design of multi stimuli-responsive nanomicelles sensitive to redox potential, pH, and temperature was reported recently [217].”
BackgroundMultiple stimuli-responsive polymeric micelles for controlled release
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- Authors
- Klaikherd, A., Nagamani, C., & Thayumanavan, S.
- Affiliations
- University of Massachusetts Amherst (US)
- Corresponding author
- Thayumanavan, S.
- ORCID
- Thayumanavan, S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-03-16
- Volume
- 131
- Issue
- 13
- Pages
- 4830-4838
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- PMC
- PMC2693022
- OpenAlex
- W1992741184
- Cited by
- 594
- References
- 94
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 15 · 2023: 10 · 2022: 10 · 2021: 26 · 2020: 24 · 2019: 35 · 2018: 32 · 2017: 54 · 2016: 45 · 2015: 51 · 2014: 65 · 2013: 49 · 2012: 57
- FWCI
- 24.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Chemical Society (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
- Scholarworks (University of Massachusetts Amherst) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM065255)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- stimuli-responsive polymers, amphiphilic block copolymers, thermoresponsive polymers, pH-responsive polymers, redox-responsive polymers, poly(N-isopropylacrylamide), HEMA, disulfide bonds, micelles, controlled release kinetics
- MeSH terms
- Acids, Acrylamides, Acrylic Resins, Drug Carriers, Hydrogen-Ion Concentration, Kinetics, Methacrylates, Micelles, Magnetic Resonance Spectroscopy, Oxazines, Oxidation-Reduction, Polymers, Pyrans, Temperature, Water, Hydrophobic and Hydrophilic Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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