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Cortistatins A, B, C, and D, Anti-angiogenic Steroidal Alkaloids, from the Marine Sponge Corticium simplex
Abstract
Four novel steroidal alkaloids named cortistatins A (1), B (2), C (3), and D (4) consisting of a 9(10-19)-abeo-androstane and isoquinoline skeleton have been isolated from the marine sponge Corticium simplex. The absolute stereostructures of 1-4 were elucidated by detailed 2D NMR, CD, and X-ray crystallographic analyses. Cortistatins A-D inhibited proliferation of human umbilical vein endothelial cells (HUVECs) with high selectivity. Among the four substances, cortistatin A (1) showed the strongest anti-proliferative activity (IC50 = 0.0018 muM) against HUVECs, in which the selective index was more than 3000-fold in comparison with that of normal fibroblast or several tumor cell lines.
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Cited by
Faulkner, D. J. (1990) · Natural Product Reports · doi:10.1039/np9900700269 · Cited by 4,866
Mehbub, M., Lei, J., Franco, C., & Zhang, W. (2014) · Marine Drugs · doi:10.3390/md12084539 · Cited by 417
Chemoselectivity: The Mother of Invention in Total Synthesis
Shenvi, R. A., O’Malley, D. P., & Baran, P. S. (2009) · Accounts of Chemical Research · doi:10.1021/ar800182r · Cited by 334
Marine-derived angiogenesis inhibitors for cancer therapy
Wang, Y.-Q., & Miao, Z.-H. (2013) · Marine Drugs · doi:10.3390/md11030903 · Cited by 72
Han, B.-N., Hong, L.-L., Gu, B.-B., Sun, Y.-T., Wang, J., Liu, J.-T., & Lin, H.-W. (2019) · Symbiotic Microbiomes of Coral Reefs Sponges and Corals · doi:10.1007/978-94-024-1612-1_15 · Cited by 39
Metadata
- Authors
- Aoki, S., Watanabe, Y., Sanagawa, M., Setiawan, A., Kotoku, N., & Kobayashi, M.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-02-17
- Volume
- 128
- Issue
- 10
- Pages
- 3148-3149
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2011988218
- Cited by
- 293
- References
- 0
- FWCI
- 12.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cortistatins A, B, C, and D, Anti-angiogenic Steroidal Alkaloids, from the Marine Sponge Corticium simplex. https://app.cochat.ai/papers/10.1021/ja057404h
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- Aoki, S., Watanabe, Y., Sanagawa, M., Setiawan, A., Kotoku, N., & Kobayashi, M. (2006). Cortistatins A, B, C, and D, Anti-angiogenic Steroidal Alkaloids, from the Marine Sponge Corticium simplex. Journal of the American Chemical Society. https://doi.org/10.1021/ja057404h
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