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Enzyme Catalysis: Tool to Make and Break Amygdalin Hydrogelators from Renewable Resources: A Delivery Model for Hydrophobic Drugs
Abstract
We report a novel approach for the controlled delivery of an antiinflammatory, chemopreventive drug by an enzyme-triggered drug release mechanism via the degradation of encapsulated hydrogels. The hydro- and organogelators are synthesized in high yields from renewable resources by using regioselective enzyme catalysis, and a known chemopreventive and antiinflammatory drug, i.e., curcumin, is used for the model study. The release of the drug occurred at physiological temperature, and control of the drug release rate is achieved by manipulating the enzyme concentration and/or temperature. The byproducts formed after the gel degradation were characterized and clearly demonstrated the site specificity of degradation of the gelator by enzyme catalysis. The present approach could have applications in developing cost-effective controlled drug delivery vehicles from renewable resources, with a potential impact on pharmaceutical research and molecular design and delivery strategies.
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Cited by
Sahu, A., Kasoju, N., & Bora, U. (2008) · Biomacromolecules · doi:10.1021/bm800683f · Cited by 548
Synthesis and characterisation of zein–curcumin colloidal particles
Patel, A., Hu, Y., Tiwari, J. K., & Velikov, K. P. (2010) · Soft Matter · doi:10.1039/c0sm00800a · Cited by 484
Cu(I)-Catalyzed Click Chemistry in Glycoscience and Their Diverse Applications
Agrahari, A. K., Bose, P., Jaiswal, M. K., Rajkhowa, S., Singh, A. S., Hotha, S., Mishra, N., & Tiwari, V. K. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00920 · Cited by 445
Tapal, A., & Tiku, P. K. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2011.08.025 · Cited by 349
Anitha, A., Maya, S., Deepa, N., Chennazhi, K. P., Nair, S. V., Tamura, H., & Jayakumar, R. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.08.008 · Cited by 347
Metadata
- Authors
- Vemula, P. K., Li, J., & John, G.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-06-20
- Volume
- 128
- Issue
- 27
- Pages
- 8932-8938
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1991660232
- Cited by
- 300
- References
- 0
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vemula, P. K., Li, J., & John, G. (2006). Enzyme Catalysis: Tool to Make and Break Amygdalin Hydrogelators from Renewable Resources: A Delivery Model for Hydrophobic Drugs. Journal of the American Chemical Society. https://doi.org/10.1021/ja062650u
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