The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Effect of Surface Functionalization of MCM-41-Type Mesoporous Silica Nanoparticles on the Endocytosis by Human Cancer Cells
Abstract
We have synthesized a series of MCM-41-type mesoporous silica nanoparticles (MSN). The surface of the MSNs are functionalized with 3-aminopropyl (AP), 3-guanidinopropyl (GP), 3-[N-(2-guanidinoethyl)guanidino]propyl (GEGP), and N-folate-3-aminopropyl (FAP). In contrast to the zeta-potential of -18.4 mV for FITC-MSN, the values of zeta-potential for AP-, GP-, GEGP-, and FAP-functionalized FITC-MSNs in 100 mM PBS buffer (pH 7.4) increased positively from -11.3, -10.6, -4.0, to +4.9 mV, respectively. The uptake efficiency, endocytosis mechanism, and biocompatibility of these organically functionalized MSNs were investigated with human cervical cancer cells (HeLa). Flow cytometry results suggested that the endocytosis of MSN could be manipulated by different surface functionalization. The immunocytochemistry study indicated that the uptake of these MSNs by HeLa cells was surface functional group dependent and involved several different mechanisms of endocytosis. Confocal fluorescence micrographs showed that the different surface functionalities of MSNs could also affect their ability to escape endosomal entrapment, which is a key factor in designing effective intracellular delivery vehicles.
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Szabo, I. (1999) · The EMBO Journal · doi:10.1093/emboj/18.20.5517 · Cited by 278
Uptake of Silica-Coated Nanoparticles by HeLa Cells
Xing, X., He, X., Peng, J., Wang, K., & Tan, W. (2005) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2005.199 · Cited by 128
Folate‐maytansinoids: Target‐selective drugs of low molecular weight
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Gruenhagen, J., Lai, C., Radu, D. R., Lin, V. S. ‐., & Yeung, E. S. (2005) · Applied Spectroscopy · doi:10.1366/0003702053641513 · Cited by 73
Self-citationPark, K. M., & Schuster, G. B. (1992) · The Journal of Organic Chemistry · doi:10.1021/jo00034a060 · Cited by 42
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The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems
Albanese, A., Tang, P. S., & Chan, W. C. W. (2012) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071811-150124 · Cited by 3,633
Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers☆
SLOWING, I., VIVEROESCOTO, J., WU, C., & LIN, V (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.012 · Cited by 2,653
Self-citationMesoporous silica nanoparticles in biomedical applications
Li, Z., Barnes, J. C., Bosoy, A., Stoddart, J. F., & Zink, J. I. (2012) · Chemical Society Reviews · doi:10.1039/c1cs15246g · Cited by 1,907
Biodegradable luminescent porous silicon nanoparticles for in vivo applications
Park, J.-H., Gu, L., von Maltzahn, G., Ruoslahti, E., Bhatia, S. N., & Sailor, M. J. (2009) · Nature Materials · doi:10.1038/nmat2398 · Cited by 1,897
Mesoporous silica nanoparticles for drug delivery and biosensing applications
Slowing, I. I., Trewyn, B. G., Giri, S., & Lin, V. S. ‐. (2007) · Advanced Functional Materials · doi:10.1002/adfm.200601191 · Cited by 1,699
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Metadata
- Authors
- Slowing, I., Trewyn, B. G., & Lin, V. S.-Y.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-11-01
- Volume
- 128
- Issue
- 46
- Pages
- 14792-14793
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1993390114
- Cited by
- 846
- References
- 6
- FWCI
- 17.63
- Type
- journal article
- Language
- en
- Open access
- closed
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