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A Smart Magnetic Resonance Contrast Agent for Selective Copper Sensing
Abstract
We describe the synthesis and properties of Copper-Gad-1 (CG1), a new type of smart magnetic resonance (MR) sensor for selective detection of copper. CG1 is composed of a gadolinium contrast agent core tethered to copper-selective recognition motif. Cu2+-induced modulation of inner-sphere water access to the Gd3+ center provides a sensing mechanism for reporting Cu2+ levels by reading out changes in longitudinal proton relaxivity values. CG1 features good selectivity for Cu2+ over abundant biological cations and a 41% increase in relaxivity upon Cu2+ binding and is capable of detecting micromolar changes in Cu2+ concentrations in aqueous media.
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Haas, K. L., & Franz, K. J. (2009) · Chemical Reviews · doi:10.1021/cr900134a · Cited by 984
Que, E. L., & Chang, C. J. (2010) · Chem. Soc. Rev. · doi:10.1039/b914348n · Cited by 263
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Metadata
- Authors
- Que, E. L., & Chang, C. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-11-24
- Volume
- 128
- Issue
- 50
- Pages
- 15942-15943
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2063074514
- Cited by
- 164
- References
- 1
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
