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Cited by 766

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Hybrid Gadolinium Oxide Nanoparticles: Multimodal Contrast Agents for in Vivo Imaging

Open access
Bridot, Jean-Luc, Faure, Anne-Charlotte, Laurent, Sophie, Rivière, Charlotte, Billotey, Claire, Hiba, Bassem, Janier, Marc, Josserand, Véronique, Coll, Jean-Luc, Vander Elst, Luce, Muller, Robert, Roux, Stéphane, Perriat, Pascal, Tillement, Olivier·2007·Journal of the American Chemical Society

Abstract

Luminescent hybrid nanoparticles with a paramagnetic Gd2O3 core were applied as contrast agents for both in vivo fluorescence and magnetic resonance imaging. These hybrid particles were obtained by encapsulating Gd2O3 cores within a polysiloxane shell which carries organic fluorophores and carboxylated PEG covalently tethered to the inorganic network. Longitudinal proton relaxivities of these particles are higher than the positive contrast agents like Gd-DOTA which are commonly used for clinical magnetic resonance imaging. Moreover these particles can be followed up by fluorescence imaging. This study revealed that these particles suited for dual modality imaging freely circulate in the blood vessels without undesirable accumulation in lungs and liver.

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Crossref · 10.1021/ja068356j

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Metadata

Authors
Bridot, J.-L., Faure, A.-C., Laurent, S., Rivière, C., Billotey, C., Hiba, B., Janier, M., Josserand, V., Coll, J.-L., Vander Elst, L., Muller, R., Roux, S., Perriat, P., & Tillement, O.
Venue
Journal of the American Chemical Society
Published
2007-03-31
Volume
129
Issue
16
Pages
5076-5084
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
OpenAlex
W2012331414
Cited by
766
References
1
FWCI
25.05
Type
journal article
Language
en
Open access
green

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