Cited by 1,238Nanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsDendrimers and Hyperbranched Polymers

Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems

Nasongkla, Norased, Bey, Erik, Ren, Jimin, Ai, Hua, Khemtong, Chalermchai, Guthi, Jagadeesh Setti, Chin, Shook-Fong, Sherry, A. Dean +2 more·2006·Nano Letters

Abstract

We describe the development of multifunctional polymeric micelles with cancer-targeting capability via alpha(v)beta(3) integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to alpha(v)beta(3)-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles.

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Crossref · 10.1021/nl061412u

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Authors
Nasongkla, N., Bey, E., Ren, J., Ai, H., Khemtong, C., Guthi, J. S., Chin, S.-F., Sherry, A. D., Boothman, D. A., & Gao, J.
Affiliations
Harold C. Simmons Comprehensive Cancer Center (US)
Corresponding author
Gao, Jinming
Venue
Nano Letters
Published
2006-10-24
Volume
6
Issue
11
Pages
2427-2430
ISSN
  • 1530-6984 (ISSN-L)
  • 1530-6992
OpenAlex
W2110688302
Cited by
1,238
References
16
Citations by year
2026: 5 · 2025: 15 · 2024: 17 · 2023: 14 · 2022: 26 · 2021: 30 · 2020: 40 · 2019: 59 · 2018: 54 · 2017: 74 · 2016: 97 · 2015: 84 · 2014: 95 · 2013: 104 · 2012: 115
FWCI
35.32
Type
journal article
Language
en
Open access
closed
Locations
  • Nano Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Cancer Institute (R01CA090696, R01CA102792, P30CA142543)
  • National Institute of Biomedical Imaging and Bioengineering (R21EB005394)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
Keywords
polymeric micelles, multifunctional drug delivery, cRGD peptide, superparamagnetic iron oxide nanoparticles, doxorubicin, MRI contrast agents, targeted cancer therapy, cytotoxicity, tumor targeting
MeSH terms
Dose-Response Relationship, Drug, Doxorubicin, Ferric Compounds, Humans, Hydrogen-Ion Concentration, Ligands, Magnetic Resonance Imaging, Micelles, Neoplasms, Oligopeptides, Polymers, Sensitivity and Specificity, Structure-Activity Relationship, Surface Properties, Drug Delivery Systems, Integrin alphaVbeta3, Cell Line, Tumor, Cell Proliferation, Nanoparticles

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