Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems
Abstract
We describe the development of multifunctional polymeric micelles with cancer-targeting capability via alpha(v)beta(3) integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to alpha(v)beta(3)-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles.
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Iron oxide nanoparticles can be entrapped inside vesicles like liposomes or polymeric micelles.
“Iron oxide nanoparticles can be entrapped inside of vesicles like liposomes [94–97] or polymeric micelles [98–101].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [99]
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- Authors
- Nasongkla, N., Bey, E., Ren, J., Ai, H., Khemtong, C., Guthi, J. S., Chin, S.-F., Sherry, A. D., Boothman, D. A., & Gao, J.
- Affiliations
- Harold C. Simmons Comprehensive Cancer Center (US)
- Corresponding author
- Gao, Jinming
- ORCID
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-10-24
- Volume
- 6
- Issue
- 11
- Pages
- 2427-2430
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2110688302
- Cited by
- 1,238
- References
- 16
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 17 · 2023: 14 · 2022: 26 · 2021: 30 · 2020: 40 · 2019: 59 · 2018: 54 · 2017: 74 · 2016: 97 · 2015: 84 · 2014: 95 · 2013: 104 · 2012: 115
- FWCI
- 35.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nano Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA090696, R01CA102792, P30CA142543)
- National Institute of Biomedical Imaging and Bioengineering (R21EB005394)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- polymeric micelles, multifunctional drug delivery, cRGD peptide, superparamagnetic iron oxide nanoparticles, doxorubicin, MRI contrast agents, targeted cancer therapy, cytotoxicity, tumor targeting
- MeSH terms
- Dose-Response Relationship, Drug, Doxorubicin, Ferric Compounds, Humans, Hydrogen-Ion Concentration, Ligands, Magnetic Resonance Imaging, Micelles, Neoplasms, Oligopeptides, Polymers, Sensitivity and Specificity, Structure-Activity Relationship, Surface Properties, Drug Delivery Systems, Integrin alphaVbeta3, Cell Line, Tumor, Cell Proliferation, Nanoparticles
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