The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Modular Multi-Level Circuits from Immobilized DNA-Based Logic Gates
Abstract
One of the fundamental goals of molecular computing is to reproduce the tenets of digital logic, such as component modularity and hierarchical circuit design. An important step toward this goal is the creation of molecular logic gates that can be rationally wired into multi-level circuits. Here we report the design and functional characterization of a complete set of modular DNA-based Boolean logic gates (AND, OR, and AND-NOT) and further demonstrate their wiring into a three-level circuit that exhibits Boolean XOR (exclusive OR) function. The approach is based on solid-supported DNA logic gates that are designed to operate with single-stranded DNA inputs and outputs. Since the solution-phase serves as the communication medium between gates, circuit wiring can be achieved by designating the DNA output of one gate as the input to another. Solid-supported logic gates provide enhanced gate modularity versus solution-phase systems by significantly simplifying the task of choosing appropriate DNA input and output sequences used in the construction of multi-level circuits. The molecular logic gates and circuits reported here were characterized by coupling DNA outputs to a single-input REPORT gate and monitoring the resulting fluorescent output signals.
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Citations
Cites
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Enzyme-Free Nucleic Acid Logic Circuits
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DINAMelt web server for nucleic acid melting prediction
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A deoxyribozyme-based molecular automaton
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Cited by
Dynamic DNA nanotechnology using strand-displacement reactions
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Control of DNA Strand Displacement Kinetics Using Toehold Exchange
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Deng, R., Tang, L., Tian, Q., Wang, Y., Lin, L., & Li, J. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201309388 · Cited by 450
All-photonic multifunctional molecular logic device
Andréasson, J., Pischel, U., Straight, S. D., Moore, T. A., Moore, A. L., & Gust, D. (2011) · Journal of the American Chemical Society · doi:10.1021/ja203456h · Cited by 350
Metadata
- Authors
- Frezza, B. M., Cockroft, S. L., & Ghadiri, M. R.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-11-10
- Volume
- 129
- Issue
- 48
- Pages
- 14875-14879
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2069755600
- Cited by
- 276
- References
- 38
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Frezza, B. M., Cockroft, S. L., & Ghadiri, M. R. (2007). Modular Multi-Level Circuits from Immobilized DNA-Based Logic Gates. Journal of the American Chemical Society. https://doi.org/10.1021/ja0710149
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
