The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Soluble Single-Walled Carbon Nanotubes as Longboat Delivery Systems for Platinum(IV) Anticancer Drug Design
Open accessAbstract
Amine-functionalized soluble single-walled carbon nanotubes (SWNTs) were derivatized with cisplatin prodrug conjugates as a delivery system by which to internalize multiple prodrug centers. The platinum(IV) complex, c, c, t -[Pt(NH 3 ) 2 Cl 2 (OEt)(O 2 CCH 2 CH 2 CO 2 H)], was tethered to the surface of the carbon nanotubes through peptide linkages formed by the reaction of the SWNT-tethered amines with the carboxylate moiety. The SWNTs were taken into testicular cancer cells by endocytosis, where the drop in pH facilitates reductive release of the platinum(II) core complex, which then readily diffuses throughout the cell, as determined by platinum atomic absorption spectroscopy. The entrapment of the SWNTs within the endosomes was confirmed by fluorescence microscopy of SWNTs containing both tethered fluorescein and platinum units. The cytotoxicity of the free platinum(IV) complex increases by >100-fold when the complex is attached to the surface of the functionalized SWNTs.
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Citations
Cites
Cellular processing of platinum anticancer drugs
Wang, D., & Lippard, S. J. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1691 · Cited by 3,801
Self-citation
Cited by
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
He, C., Lu, K., Liu, D., & Lin, W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja4098862 · Cited by 885
Nanoscale Coordination Polymers for Platinum-Based Anticancer Drug Delivery
Rieter, W. J., Pott, K. M., Taylor, K. M. L., & Lin, W. (2008) · Journal of the American Chemical Society · doi:10.1021/ja803383k · Cited by 803
Mechanisms of drug release in nanotherapeutic delivery systems
Wong, P. T., & Choi, S. K. (2015) · Chemical Reviews · doi:10.1021/cr5004634 · Cited by 507
Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery
Li, Y., Maciel, D., Rodrigues, J., Shi, X., & Tomás, H. (2015) · Chemical Reviews · doi:10.1021/cr500131f · Cited by 478
Metadata
- Authors
- Feazell, R. P., Nakayama-Ratchford, N., Dai, H., & Lippard, S. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-06-15
- Volume
- 129
- Issue
- 27
- Pages
- 8438-8439
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2015343501
- Cited by
- 616
- References
- 1
- FWCI
- 27.20
- Type
- journal article
- Language
- en
- Open access
- green
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