Cited by 3,801Metal complexes synthesis and propertiesDNA Repair MechanismsCancer therapeutics and mechanisms

Cellular processing of platinum anticancer drugs

Wang, Dong, Lippard, Stephen J.·2005·Nature Reviews Drug Discovery

Abstract

Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in cancer chemotherapy. Platinum-DNA adducts, which are formed following uptake of the drug into the nucleus of cells, activate several cellular processes that mediate the cytotoxicity of these platinum drugs. This review focuses on recently discovered cellular pathways that are activated in response to cisplatin, including those involved in regulating drug uptake, the signalling of DNA damage, cell-cycle checkpoints and arrest, DNA repair and cell death. Such knowledge of the cellular processing of cisplatin adducts with DNA provides valuable clues for the rational design of more efficient platinum-based drugs as well as the development of new therapeutic strategies.

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Crossref · 10.1038/nrd1691

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230 of 230 references verified0 citation errors · 0 not checkable

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Authors
Wang, D., & Lippard, S. J.
Affiliations
Massachusetts Institute of Technology (US)
Corresponding author
Lippard, Stephen J.
Venue
Nature Reviews Drug Discovery
Published
2005-03-24
Volume
4
Issue
4
Pages
307-320
ISSN
  • 1474-1776 (ISSN-L)
  • 1474-1784
OpenAlex
W1974693247
Cited by
3,801
References
230
Citations by year
2026: 109 · 2025: 132 · 2024: 178 · 2023: 177 · 2022: 196 · 2021: 235 · 2020: 240 · 2019: 226 · 2018: 235 · 2017: 249 · 2016: 222 · 2015: 205 · 2014: 216 · 2013: 205 · 2012: 198
FWCI
10.57
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Drug Discovery (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute
Topics
  • Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer therapeutics and mechanisms
Keywords
cisplatin, carboplatin, oxaliplatin, platinum anticancer drugs, platinum-DNA adducts, drug uptake, DNA damage signaling, cell cycle checkpoints, DNA repair, cell death, cytotoxicity, rational drug design
MeSH terms
Animals, Antineoplastic Agents, Cell Survival, DNA Damage, DNA Repair, Humans, Organoplatinum Compounds, Tumor Cells, Cultured, Molecular Structure, Signal Transduction, Apoptosis

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