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Cited by 443

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Mimicry of Antimicrobial Host-Defense Peptides by Random Copolymers

Mowery, Brendan P., Lee, Sarah E., Kissounko, Denis A., Epand, Raquel F., Epand, Richard M., Weisblum, Bernard, Stahl, Shannon S., Gellman, Samuel H.·2007·Journal of the American Chemical Society
DOI 10.1021/ja077288d
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Abstract

Efforts to generate antibacterial agents via mimicry of host-defense peptides have focused on discrete oligomers that can adopt a regular globally amphiphilic conformation in the presence of bacterial cell membranes and ultimately disrupt those membranes. Although considerable success has been achieved with this approach, application of the resulting molecules is hampered by the high cost associated with stepwise oligomer synthesis. We show that random poly-β-peptide copolymers, prepared by ring-opening polymerization of β-lactams, can be tuned to display good activity against a panel of four bacteria along with low lytic activity toward human red blood cells. These findings support a nonclassical design hypothesis for antibacterial agents.

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Metadata

Authors
Mowery, B. P., Lee, S. E., Kissounko, D. A., Epand, R. F., Epand, R. M., Weisblum, B., Stahl, S. S., & Gellman, S. H.
Venue
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Published
2007-11-23
Volume
129
Issue
50
Pages
15474-15476
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
DOI
10.1021/ja077288d
OpenAlex
W2094446407
Cited by
443
References
2
FWCI
16.91
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.