Antimicrobial Polymers
Abstract
Better health is basic requirement of human being, but the rapid growth of harmful pathogens and their serious health effects pose a significant challenge to modern science. Infections by pathogenic microorganisms are of great concern in many fields such as medical devices, drugs, hospital surfaces/furniture, dental restoration, surgery equipment, health care products, and hygienic applications (e.g., water purification systems, textiles, food packaging and storage, major or domestic appliances etc.) Antimicrobial polymers are the materials having the capability to kill/inhibit the growth of microbes on their surface or surrounding environment. Recently, they gained considerable interest for both academic research and industry and were found to be better than their small molecular counterparts in terms of enhanced efficacy, reduced toxicity, minimized environmental problems, resistance, and prolonged lifetime. Hence, efforts have focused on the development of antimicrobial polymers with all desired characters for optimum activity. In this Review, an overview of different antimicrobial polymers, their mechanism of action, factors affecting antimicrobial activity, and application in various fields are given. Recent advances and the current clinical status of these polymers are also discussed.
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QPEI is a synthetic, non-biodegradable, cationic polymer with primary, secondary, and tertiary amine functionalities that can undergo chemical modifications to produce desirable physicochemical properties.
“The QPEI is a synthetic, non-biodegradable, cationic polymer with primary, secondary and tertiary amine functionalities, which may be subjected to a wide range of chemical modifications to produce desirable physicochemical properties [16].”
From Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance (2017) · cites this paper as [16]
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- Authors
- Jain, A., Duvvuri, L. S., Farah, S., Beyth, N., Domb, A. J., & Khan, W.
- Affiliations
- National Institute of Pharmaceutical Education and Research (IN)
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Domb, Abraham J.
- Khan, Wahid
- Venue
- Advanced Healthcare Materials
- Publisher
- Wiley
- Published
- 2014-11-19
- Volume
- 3
- Issue
- 12
- Pages
- 1969-1985
- ISSN
- 2192-2640 (ISSN-L)
- 2192-2659
- OpenAlex
- W4211217504
- Cited by
- 485
- References
- 135
- Citations by year
- 2026: 17 · 2025: 31 · 2024: 57 · 2023: 58 · 2022: 49 · 2021: 70 · 2020: 46 · 2019: 49 · 2018: 36 · 2017: 24 · 2016: 32 · 2015: 5 · 2014: 4
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Healthcare Materials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Physical Sciences › Engineering › Building and Construction › Dyeing and Modifying Textile Fibers
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- antimicrobial polymers, antimicrobial mechanisms, antimicrobial activity, pathogenic microorganisms, medical devices, hospital surfaces, food packaging, textiles, water purification, dental restorations, surgical equipment, clinical application
- MeSH terms
- Animals, Anti-Infective Agents, Clinical Trials as Topic, Humans, Polymers, Swine, Drug Delivery Systems, Coated Materials, Biocompatible, Nanostructures
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