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Functional Hyperbranched Polymers: Toward Targeted in Vivo 19F Magnetic Resonance Imaging Using Designed Macromolecules

Thurecht, Kristofer J., Blakey, Idriss, Peng, Hui, Squires, Oliver, Hsu, Steven, Alexander, Cameron, Whittaker, Andrew K.·2010·Journal of the American Chemical Society

Abstract

We have demonstrated the design and synthesis of hyperbranched molecules that can be successfully imaged in vivo using (19)F MRI in under 10 min. These polymers are cytocompatible following chain extension with PEGMA. In addition, functionalization of these macromolecules can be achieved in a facile manner and with accessible and correct ligand presentation. Such hyperbranched polymers hold promise as new generation tracking and targeting MRI contrast agents.

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Crossref · 10.1021/ja100252y

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Metadata

Authors
Thurecht, K. J., Blakey, I., Peng, H., Squires, O., Hsu, S., Alexander, C., & Whittaker, A. K.
Venue
Journal of the American Chemical Society
Published
2010-03-26
Volume
132
Issue
15
Pages
5336-5337
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
OpenAlex
W1988298305
Cited by
185
References
1
FWCI
10.73
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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