Toxicity of cationic lipids and cationic polymers in gene delivery
Abstract
Gene therapy, as a promising therapeutics to treat genetic or acquired diseases, has achieved exciting development in the past two decades. Appropriate gene vectors can be crucial for gene transfer. Cationic lipids and polymers, the most important non-viral vectors, have many advantages over viral ones as non-immunogenic, easy to produce and not oncogenic. They hold the promise to replace viral vectors to be used in clinic. However, the toxicity is still an obstacle to the application of non-viral vectors to gene therapy. For overcoming the problem, many new cationic compounds have been developed. This article provides a review with respect to toxicity of cationic lipids and polymers in gene delivery. We evaluate the structural features of cationic compounds and summarize the relationship of toxicity and structure and hope to provide available suggestions on the development of these cationic compounds.
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PEGylated, neutral, and ionizable lipids are employed as stable carriers in lipid delivery systems designed specifically for siRNA.
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Cytotoxicity of lipid materials is a safety concern depending on the dose, lipid properties and cell types.
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From Lipid nanoparticles for mRNA delivery (2021) · cites this paper as [176]
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- Authors
- Lv, H., Zhang, S., Wang, B., Cui, S., & Yan, J.
- Affiliations
- Dalian Institute of Chemical Physics (CN)
- Dalian Minzu University (CN)
- Sichuan University of Science and Engineering (CN)
- Corresponding author
- Zhang, Shubiao
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 114
- Issue
- 1
- Pages
- 100-109
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2000136129
- Cited by
- 2,286
- References
- 107
- Citations by year
- 2026: 100 · 2025: 123 · 2024: 163 · 2023: 141 · 2022: 146 · 2021: 149 · 2020: 140 · 2019: 168 · 2018: 129 · 2017: 133 · 2016: 124 · 2015: 126 · 2014: 147 · 2013: 117 · 2012: 97
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Dalian Institute of Chemical Physics, CAS Institutional Repository (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- cationic lipids, cationic polymers, gene delivery, non-viral vectors, toxicity, structure-toxicity relationship, gene therapy, cationic compounds
- MeSH terms
- Animals, Cations, Lipids, Liposomes, Polylysine, Polymers, Polysaccharides, Genetic Therapy, Molecular Structure
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