The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Regenerable DNA-Functionalized Hydrogels for Ultrasensitive, Instrument-Free Mercury(II) Detection and Removal in Water
Abstract
Mercury is a highly toxic environmental pollutant with bioaccumulative properties. Therefore, new materials are required to not only detect but also effectively remove mercury from environmental sources such as water. We herein describe a polyacrylamide hydrogel-based sensor functionalized with a thymine-rich DNA that can simultaneously detect and remove mercury from water. Detection is achieved by selective binding of Hg(2+) between two thymine bases, inducing a hairpin structure where, upon addition of SYBR Green I dye, green fluorescence is observed. In the absence of Hg(2+), however, addition of the dye results in yellow fluorescence. Using the naked eye, the detection limit in a 50 mL water sample is 10 nM Hg(2+). This sensor can be regenerated using a simple acid treatment and can remove Hg(2+) from water at a rate of approximately 1 h(-1). This sensor was also used to detect and remove Hg(2+) from samples of Lake Ontario water spiked with mercury. In addition, these hydrogel-based sensors are resistant to nuclease and can be rehydrated from dried gels for storage and DNA protection. Similar methods can be used to functionalize hydrogels with other nucleic acids, proteins, and small molecules for environmental and biomedical applications.
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Cites
Hazards of heavy metal contamination
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Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology
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Tools and Tactics for the Optical Detection of Mercuric Ion
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Functionalized Monolayers on Ordered Mesoporous Supports
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Self-citationThe Chemical Form of Mercury in Fish
Harris, H. H., Pickering, I. J., & George, G. N. (2003) · Science · doi:10.1126/science.1085941 · Cited by 1,353
Lee, J., Han, M. S., & Mirkin, C. A. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200700269 · Cited by 1,308
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A reversibly antigen-responsive hydrogel
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Highly Selective Oligonucleotide‐Based Sensor for Mercury(II) in Aqueous Solutions
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MercuryII-Mediated Formation of Thymine−HgII−Thymine Base Pairs in DNA Duplexes
Miyake, Y., Togashi, H., Tashiro, M., Yamaguchi, H., Oda, S., Kudo, M., Tanaka, Y., Kondo, Y., Sawa, R., Fujimoto, T., et al. (2006) · Journal of the American Chemical Society · doi:10.1021/ja056354d · Cited by 1,079
Cited by
Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy
Meng, H.-M., Liu, H., Kuai, H., Peng, R., Mo, L., & Zhang, X.-B. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00645g · Cited by 608
Ai, K., Ruan, C., Shen, M., & Lu, L. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201601338 · Cited by 441
Li, C., Faulkner‐Jones, A., Dun, A. R., Jin, J., Chen, P., Xing, Y., Yang, Z., Li, Z., Shu, W., Liu, D., et al. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201411383 · Cited by 423
Döring, A., Birnbaum, W., & Kuckling, D. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60031a · Cited by 391
Polymeric DNA hydrogel: Design, synthesis and applications
Li, F., Tang, J., Geng, J., Luo, D., & Yang, D. (2019) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2019.101163 · Cited by 308
Metadata
- Authors
- Dave, N., Chan, M. Y., Huang, P.-J. J., Smith, B. D., & Liu, J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-08-20
- Volume
- 132
- Issue
- 36
- Pages
- 12668-12673
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1973695166
- Cited by
- 461
- References
- 46
- FWCI
- 11.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dave, N., Chan, M. Y., Huang, P.-J. J., Smith, B. D., & Liu, J. (2010). Regenerable DNA-Functionalized Hydrogels for Ultrasensitive, Instrument-Free Mercury(II) Detection and Removal in Water. Journal of the American Chemical Society. https://doi.org/10.1021/ja106098j
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