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Colorimetric Bacteria Sensing Using a Supramolecular Enzyme–Nanoparticle Biosensor
Open accessAbstract
Rapid and sensitive detection of pathogens is a key requirement for both environmental and clinical settings. We report here a colorimetric enzyme-nanoparticle conjugate system for detection of microbial contamination. In this approach, cationic gold nanoparticles (NPs) featuring quaternary amine headgroups are electrostatically bound to an enzyme [β-galactosidase (β-Gal)], inhibiting enzyme activity. Analyte bacteria bind to the NP, which releases the β-Gal and restores its activity, providing an enzyme-amplified colorimetric readout of the binding event. Using this strategy, we have been able to quantify bacteria at concentrations of 1 × 10(2) bacteria/mL in solution and 1 × 10(4) bacteria/mL in a field-friendly test strip format.
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Citations
Cited by
Gold Nanoparticles in Chemical and Biological Sensing
Saha, K., Agasti, S. S., Kim, C., Li, X., & Rotello, V. M. (2012) · Chemical Reviews · doi:10.1021/cr2001178 · Cited by 4,620
Self-citationDiverse Applications of Nanomedicine
Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.6b06040 · Cited by 1,350
Self-citationBiosensors for Whole-Cell Bacterial Detection
Ahmed, A., Rushworth, J. V., Hirst, N. A., & Millner, P. A. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00120-13 · Cited by 666
Nanomaterials for targeted detection and photothermal killing of bacteria
Ray, P. C., Khan, S. A., Singh, A. K., Senapati, D., & Fan, Z. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15340h · Cited by 485
Colorimetric sensors for rapid detection of various analytes
Piriya V.S, A., Joseph, P., Daniel S.C.G., K., Lakshmanan, S., Kinoshita, T., & Muthusamy, S. (2017) · Materials Science and Engineering: C · doi:10.1016/j.msec.2017.05.018 · Cited by 441
Metadata
- Authors
- Miranda, O. R., Li, X., Garcia-Gonzalez, L., Zhu, Z.-J., Yan, B., Bunz, U. H. F., & Rotello, V. M.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-06-07
- Volume
- 133
- Issue
- 25
- Pages
- 9650-9653
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2076012434
- Cited by
- 359
- References
- 0
- FWCI
- 14.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Miranda, O. R., Li, X., Garcia-Gonzalez, L., Zhu, Z.-J., Yan, B., Bunz, U. H. F., & Rotello, V. M. (2011). Colorimetric Bacteria Sensing Using a Supramolecular Enzyme–Nanoparticle Biosensor. Journal of the American Chemical Society. https://doi.org/10.1021/ja2021729
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
