The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Reaction-Based Fluorescent Probes for Selective Imaging of Hydrogen Sulfide in Living Cells
Abstract
Hydrogen sulfide (H(2)S) is emerging as an important mediator of human physiology and pathology but remains difficult to study, in large part because of the lack of methods for selective monitoring of this small signaling molecule in live biological specimens. We now report a pair of new reaction-based fluorescent probes for selective imaging of H(2)S in living cells that exploit the H(2)S-mediated reduction of azides to fluorescent amines. Sulfidefluor-1 (SF1) and Sulfidefluor-2 (SF2) respond to H(2)S by a turn-on fluorescence signal enhancement and display high selectivity for H(2)S over other biologically relevant reactive sulfur, oxygen, and nitrogen species. In addition, SF1 and SF2 can be used to detect H(2)S in both water and live cells, providing a potentially powerful approach for probing H(2)S chemistry in biological systems.
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Citations
Cites
H 2 S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
Yang, G., Wu, L., Jiang, B., Yang, W., Qi, J., Cao, K., Meng, Q., Mustafa, A. K., Mu, W., Zhang, S., et al. (2008) · Science · doi:10.1126/science.1162667 · Cited by 2,310
Glutathione in Cancer Biology and Therapy
Estrela, J. M., Ortega, A., & Obrador, E. (2006) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360500523878 · Cited by 1,041
Molecular imaging of hydrogen peroxide produced for cell signaling
Miller, E. W., Tulyathan, O., Isacoff, E. Y., & Chang, C. J. (2007) · Nature Chemical Biology · doi:10.1038/nchembio871 · Cited by 450
Self-citation
Cited by
BODIPY-based probes for the fluorescence imaging of biomolecules in living cells
Kowada, T., Maeda, H., & Kikuchi, K. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00030k · Cited by 1,381
Hydrogen sulfide chemical biology: pathophysiological roles and detection
Kolluru, G. K., Shen, X., Bir, S. C., & Kevil, C. G. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.07.002 · Cited by 480
Chemical foundations of hydrogen sulfide biology
Li, Q., & Lancaster, J. R. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.07.001 · Cited by 334
Thiol Reactive Probes and Chemosensors
Peng, H., Chen, W., Cheng, Y., Hakuna, L., Strongin, R., & Wang, B. (2012) · Sensors · doi:10.3390/s121115907 · Cited by 275
Wang, R., Yu, F., Chen, L., Chen, H., Wang, L., & Zhang, W. (2012) · Chemical Communications · doi:10.1039/c2cc36088h · Cited by 262
Metadata
- Authors
- Lippert, A. R., New, E. J., & Chang, C. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-06-15
- Volume
- 133
- Issue
- 26
- Pages
- 10078-10080
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2045070686
- Cited by
- 760
- References
- 3
- FWCI
- 28.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lippert, A. R., New, E. J., & Chang, C. J. (2011). Reaction-Based Fluorescent Probes for Selective Imaging of Hydrogen Sulfide in Living Cells. Journal of the American Chemical Society. https://doi.org/10.1021/ja203661j
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