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Monosaccharide-Responsive Release of Insulin from Polymersomes of Polyboroxole Block Copolymers at Neutral pH
Abstract
We synthesized a boroxole-containing styrenic monomer that can be polymerized by the reversible addition-fragmentation and chain transfer (RAFT) method. Poly(styreneboroxole) (PBOx) and its block copolymers with a poly(ethylene glycol) (PEG) as a hydrophilic block displayed binding to monosaccharides in phosphate buffer at neutral pH, as quantified by Wang's competitive binding experiments. By virtue of a controlled radical polymerization, we were able to adjust the degree of polymerization of the PBOx block to yield sugar-responsive block copolymers that self-assembled into a variety of nanostructures including spherical and cylindrical micelles and polymer vesicles (polymersomes). Polymersomes of these block copolymers exhibited monosaccharide-responsive disassembly in a neutral-pH medium. We demonstrated the possibility of using these polymersomes as sugar-responsive delivery vehicles for insulin in neutral phosphate buffer (pH 7.4). Encapsulated insulin could be released from the polymersomes only in the presence of sugars under physiologically relevant pH conditions.
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Citations
Cited by
Stimuli-responsive nanocarriers for drug delivery
Mura, S., Nicolas, J., & Couvreur, P. (2013) · Nature Materials · doi:10.1038/nmat3776 · Cited by 6,289
The Smart Drug Delivery System and Its Clinical Potential
Liu, D., Yang, F., Xiong, F., & Gu, N. (2016) · Theranostics · doi:10.7150/thno.14858 · Cited by 1,066
Cho, S., Hwang, S. Y., Oh, D. X., & Park, J. (2021) · Journal of Materials Chemistry A · doi:10.1039/d1ta02308j · Cited by 482
Injectable Nano-Network for Glucose-Mediated Insulin Delivery
Gu, Z., Aimetti, A. A., Wang, Q., Dang, T. T., Zhang, Y., Veiseh, O., Cheng, H., Langer, R. S., & Anderson, D. G. (2013) · ACS Nano · doi:10.1021/nn400630x · Cited by 462
Stimuli-responsive nanomaterials for therapeutic protein delivery
Lu, Y., Sun, W., & Gu, Z. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.08.015 · Cited by 415
Metadata
- Authors
- Kim, H., Kang, Y. J., Kang, S., & Kim, K. T.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-02-22
- Volume
- 134
- Issue
- 9
- Pages
- 4030-4033
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2007205599
- Cited by
- 219
- References
- 0
- FWCI
- 12.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kim, H., Kang, Y. J., Kang, S., & Kim, K. T. (2012). Monosaccharide-Responsive Release of Insulin from Polymersomes of Polyboroxole Block Copolymers at Neutral pH. Journal of the American Chemical Society. https://doi.org/10.1021/ja211728x
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