Cited by 415Nanoparticle-Based Drug DeliveryHydrogels: synthesis, properties, applicationsAdvanced Drug Delivery Systems

Stimuli-responsive nanomaterials for therapeutic protein delivery

Open access
Lu, Yue, Sun, Wujin, Gu, Zhen·2014·Journal of Controlled Release

Abstract

Protein therapeutics have emerged as a significant role in treatment of a broad spectrum of diseases, including cancer, metabolic disorders and autoimmune diseases. The efficacy of protein therapeutics, however, is limited by their instability, immunogenicity and short half-life. In order to overcome these barriers, tremendous efforts have recently been made in developing controlled protein delivery systems. Stimuli-triggered release is an appealing and promising approach for protein delivery and has made protein delivery with both spatiotemporal- and dosage-controlled manners possible. This review surveys recent advances in controlled protein delivery of proteins or peptides using stimuli-responsive nanomaterials. Strategies utilizing both physiological and external stimuli are introduced and discussed.

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Crossref · 10.1016/j.jconrel.2014.08.015

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  • Wearable systems enabling stimulus-induced drug delivery that enable dose- and spatiotemporally controlled sustained release of therapeutics have been recently explored.

    “Wearable systems enabling stimulus-induced drug delivery (with the stimulus being mechanical changes or signals based on biosensor data analysis) that enable a dose- and spatiotemporally controlled sustained release of therapeutics have been recently explored [163].”

    From Wearables and the Medical Revolution (2018) · cites this paper as [163]

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Research works printed but not linked: 2

  1. [78]Tanna S Sahota T Clark J Taylor MJ Covalent coupling of concanavalin A to a Carbopol 934P and 941P carrier in glucose-sensitive gels for delivery of insulin Journal of Pharmacy and Pharmacology 2002 54 1461 1469 12495548
  2. [128]Liechty WB Chen RJ Farzaneh F Tavassoli M Slater NKH Synthetic pH-Responsive Polymers for Protein Transduction Adv Mater 2009 21 3910 22427722 PMC3303159

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Authors
Lu, Y., Sun, W., & Gu, Z.
Affiliations
University of North Carolina at Chapel Hill (US)
Corresponding author
Gu, Zhen
Venue
Journal of Controlled Release
Publisher
Elsevier BV
Published
2014-11
Volume
194
Pages
1-19
ISSN
0168-3659 (ISSN-L)
OpenAlex
W1966237056
Cited by
415
References
129
Citations by year
2026: 12 · 2025: 16 · 2024: 28 · 2023: 24 · 2022: 27 · 2021: 42 · 2020: 41 · 2019: 40 · 2018: 60 · 2017: 38 · 2016: 50 · 2015: 32 · 2014: 5
FWCI
2.84
Type
journal article
Language
en
Open access
Locations
  • Journal of Controlled Release (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
  • American Diabetes Association (550KR51307)
  • NC TraCS
  • NIH (1UL1TR001111)
  • UNC-CH
  • NCSU
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
therapeutic proteins, stimuli-responsive nanomaterials, peptide delivery, protein stability, immunogenicity, spatiotemporal drug delivery, external stimuli, physiological stimuli
MeSH terms
Animals, Humans, Proteins, Drug Delivery Systems, Nanostructures, Nanomedicine

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