Stimuli-responsive nanomaterials for therapeutic protein delivery
Open accessAbstract
Protein therapeutics have emerged as a significant role in treatment of a broad spectrum of diseases, including cancer, metabolic disorders and autoimmune diseases. The efficacy of protein therapeutics, however, is limited by their instability, immunogenicity and short half-life. In order to overcome these barriers, tremendous efforts have recently been made in developing controlled protein delivery systems. Stimuli-triggered release is an appealing and promising approach for protein delivery and has made protein delivery with both spatiotemporal- and dosage-controlled manners possible. This review surveys recent advances in controlled protein delivery of proteins or peptides using stimuli-responsive nanomaterials. Strategies utilizing both physiological and external stimuli are introduced and discussed.
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Wearable systems enabling stimulus-induced drug delivery that enable dose- and spatiotemporally controlled sustained release of therapeutics have been recently explored.
“Wearable systems enabling stimulus-induced drug delivery (with the stimulus being mechanical changes or signals based on biosensor data analysis) that enable a dose- and spatiotemporally controlled sustained release of therapeutics have been recently explored [163].”
From Wearables and the Medical Revolution (2018) · cites this paper as [163]
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- Authors
- Lu, Y., Sun, W., & Gu, Z.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Gu, Zhen
- ORCID
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 194
- Pages
- 1-19
- ISSN
- 0168-3659 (ISSN-L)
- PMC
- PMC4330094
- OpenAlex
- W1966237056
- Cited by
- 415
- References
- 129
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 28 · 2023: 24 · 2022: 27 · 2021: 42 · 2020: 41 · 2019: 40 · 2018: 60 · 2017: 38 · 2016: 50 · 2015: 32 · 2014: 5
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- American Diabetes Association (550KR51307)
- NC TraCS
- NIH (1UL1TR001111)
- UNC-CH
- NCSU
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- therapeutic proteins, stimuli-responsive nanomaterials, peptide delivery, protein stability, immunogenicity, spatiotemporal drug delivery, external stimuli, physiological stimuli
- MeSH terms
- Animals, Humans, Proteins, Drug Delivery Systems, Nanostructures, Nanomedicine
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