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A Chemical Approach for Cell-Specific Targeting of Nanomaterials: Small-Molecule-Initiated Misfolding of Nanoparticle Corona Proteins
Abstract
A major challenge in nanomaterial science is to develop approaches that ensure that when administered in vivo, nanoparticles can be targeted to their requisite site of action. Herein we report the first approach that allows for cell-specific uptake of nanomaterials by a process involving reprogramming of the behavior of the ubiquitous protein corona of nanomaterials. Specifically, judicious surface modification of quantum dots with a small molecule that induces a protein-misfolding event in a component of the nanoparticle-associated protein corona renders the associated nanomaterials susceptible to cell-specific, receptor-mediated endocytosis. We see this chemical approach as a new and general method for exploiting the inescapable protein corona to target nanomaterials to specific cells.
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“Designing the NP surface to tailor the corona is already underway, via the design of stealth particles as discussed above, or indeed via surface modification with small molecules that induce protein-misfolding in a component of the NP-associated protein corona, and which enhances or reduces the NPs’ susceptibility to cell-specific receptor-mediated endocytosis [133].”
From Particle toxicology and health - where are we? (2019) · cites this paper as [133]
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Metadata
- Authors
- Prapainop, K., Witter, D. P., & Wentworth, P.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-02-27
- Volume
- 134
- Issue
- 9
- Pages
- 4100-4103
- ISSN
- 0002-7863
- 1520-5126
- Cited by
- 105
- References
- 0
- Language
- en
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