The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
Abstract
Nanoparticles in a biological fluid (plasma, or otherwise) associate with a range of biopolymers, especially proteins, organized into the “protein corona” that is associated with the nanoparticle and continuously exchanging with the proteins in the environment. Methodologies to determine the corona and to understand its dependence on nanomaterial properties are likely to become important in bionanoscience. Here, we study the long-lived (“hard”) protein corona formed from human plasma for a range of nanoparticles that differ in surface properties and size. Six different polystyrene nanoparticles were studied: three different surface chemistries (plain PS, carboxyl-modified, and amine-modified) and two sizes of each (50 and 100 nm), enabling us to perform systematic studies of the effect of surface properties and size on the detailed protein coronas. Proteins in the corona that are conserved and unique across the nanoparticle types were identified and classified according to the protein functional properties. Remarkably, both size and surface properties were found to play a very significant role in determining the nanoparticle coronas on the different particles of identical materials. We comment on the future need for scientific understanding, characterization, and possibly some additional emphasis on standards for the surfaces of nanoparticles.
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“There is clear evidence that each of these parameters also influences the nature of the biomolecules bound [139–141], and that different coronas lead to different biodistributions of NPs in vivo, as indicated above and demonstrated by Wang et al. [142]”
From Particle toxicology and health - where are we? (2019) · cites this paper as [140]
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Vaisar, T., Pennathur, S., Green, P. S., Gharib, S. A., Hoofnagle, A. N., Cheung, M. C., Byun, J., Vuletic, S., Kassim, S., Singh, P., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci26206 · Cited by 942 · cited 9×
“The 50-nm amine-modified particles have the highest number of detected apolipoproteins, 9 of the 10 identified being associated with HDL, suggesting that 50-nm amine-modified particles associate with HDL. Apolipoprotein B-100 (the major protein in VLDL and LDL particles, but not HDL) (16) is associated with all 50-nm…”
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Monopoli, M. P., Walczyk, D., Campbell, A., Elia, G., Lynch, I., Baldelli Bombelli, F., & Dawson, K. A. (2011) · Journal of the American Chemical Society · doi:10.1021/ja107583h · Cited by 1,835
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Metadata
- Authors
- Lundqvist, M., Stigler, J., Elia, G., Lynch, I., Cedervall, T., & Dawson, K. A.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2008-09-23
- Volume
- 105
- Issue
- 38
- Pages
- 14265-14270
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 2,823
- References
- 1
- Language
- en
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- Lundqvist, M., Stigler, J., Elia, G., Lynch, I., Cedervall, T., & Dawson, K. A. (2008). Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0805135105
